Upf2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Upf2
UPF2 regulator of nonsense transcripts homolog (yeast)
MGI:2449307

27 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Lck-cre)548Jxm/? Upf2^tm1Btp/Upf2^tm1Btp involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal T cell receptor beta chain V(D)J recombination	J:134765
	decreased CD4-positive, alpha-beta T cell number	J:134765
	decreased CD8-positive, alpha-beta T cell number	J:134765
	decreased double-positive T cell number	J:134765
	thymus hypoplasia	J:134765
Upf2^tm1.1Btp/Upf2^tm1.1Btp involves: 129P2/OlaHsd	embryonic lethality, complete penetrance	J:134765
Upf2^tm1Btp/Upf2^tm1Btp En1^tm2(cre)Wrst/En1⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	abnormal cerebellum external granule cell layer morphology	J:306384
	cerebellum hypoplasia	J:306384
	decreased inferior colliculus size	J:306384
	decreased superior colliculus size	J:306384
	increased neuron apoptosis	J:306384
	increased neuronal precursor proliferation	J:306384
	loss of GABAergic neurons	J:306384
Upf2^tm1Btp/Upf2^tm1Btp Lyz2^tm1(cre)Ifo/? involves: 129P2/OlaHsd * C57BL/6 * CBA	normal immune system phenotype	J:134765
Upf2^tm1Btp/Upf2^tm1Btp Tg(Atoh1-cre)1Bfri/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal cerebellum anterior lobe morphology	J:306384
	abnormal cerebellum external granule cell layer morphology	J:306384
	decreased cerebellar granule cell number	J:306384
	increased neuronal precursor proliferation	J:306384
Upf2^tm1Btp/Upf2^tm1Btp Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal B cell number	J:134765
	abnormal bone marrow cell morphology/development	J:134765
	abnormal common lymphocyte progenitor cell morphology	J:134765
	anemia	J:134765
	decreased granulocyte number	J:134765
	decreased hematocrit	J:134765
	decreased hematopoietic stem cell number	J:134765
	decreased hemoglobin content	J:134765
	decreased T cell proliferation	J:134765
	low mean erythrocyte cell number	J:134765
	premature death	J:134765

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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