Tub Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tub
TUB bipartite transcription factor
MGI:2651573

43 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tub^m1Btlr/Tub^m1Btlr C57BL/6J-Tub^m1Btlr	increased body weight	J:221485
Tub^tm1Rok/Tub^tm1Rok C57BL/6-Tub^tm1Rok	decreased retina photoreceptor cell number	J:59994
	increased retina apoptosis	J:59994
	increased susceptibility to age related obesity	J:59994
	increased susceptibility to weight gain	J:59994
	retina degeneration	J:59994
	thin retina outer nuclear layer	J:59994
Tub^tub/Tub⁺ involves: AKR/J * B6(Cg)-Tub^tub/J	normal hearing/vestibular/ear phenotype	J:57571
Tub^tub/Tub^tub B6(AU)-Tub^tub/J	abnormal bony labyrinth	J:26067
	abnormal ear morphology	J:32415
	abnormal electroretinogram waveform feature	J:121993
	abnormal hearing physiology	J:32415
	abnormal photoreceptor inner segment morphology	J:26067
	abnormal photoreceptor outer segment morphology	J:121993
	abnormal retina neuronal layer morphology	J:121993
	abnormal retina photoreceptor layer morphology	J:26067
	abnormal retina pigment epithelium morphology	J:121993
	abnormal retina vasculature morphology	J:121993
	absent tunnel of Corti	J:26067
	cochlear ganglion degeneration	J:26067
	cochlear hair cell degeneration	J:26067
	cochlear inner hair cell degeneration	J:121993
	cochlear outer hair cell degeneration	J:26067, J:121993
	decreased retina photoreceptor cell number	J:121993
	degeneration of organ of Corti supporting cells	J:26067, J:121993
	impaired hearing	J:32415, J:121993
	increased circulating cholesterol level	J:18161
	increased circulating insulin level	J:32415
	increased circulating triglyceride level	J:18161
	increased food intake	J:32415
	increased or absent threshold for auditory brainstem response	J:121993
	increased susceptibility to age-related retinal degeneration	J:32415, J:121993
	obese	J:32415
	organ of Corti degeneration	J:26067
	photoreceptor outer segment degeneration	J:26067
	retina deposits	J:121993
	retina outer nuclear layer degeneration	J:121993
	retina photoreceptor degeneration	J:121993
Tub^tub/Tub^tub C57BL/6J-Tub^tub	abnormal Langerhans cell physiology	J:13772
	enlarged pancreatic islets	J:13772
	hepatic steatosis	J:13772
	increased circulating insulin level	J:13772
	increased liver glycogen level	J:13772
	increased total body fat amount	J:13772
	obese	J:13772
Tub^tub/Tub^tub CAST.B6-Tub^tub/Jng	normal hearing/vestibular/ear phenotype	J:57571
Tub^tub/Tub^tub involves: C57BL/6J	abnormal hypothalamus morphology	J:204140

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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