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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sesn2
sestrin 2
MGI:2651874
13 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
involves: 129P2/OlaHsd 		abnormal autophagy J:189021
abnormal gluconeogenesis J:189021
decreased adipocyte glucose uptake J:189021
decreased hepatocyte mitochondrial DNA content J:189021
decreased mitochondrial number J:189021
normal growth/size/body region phenotype J:189021
impaired glucose tolerance J:189021
increased liver triglyceride level J:189021
insulin resistance J:189021
macrovesicular hepatic steatosis J:189021
Sesn2Gt(W077E06)Wrst/Sesn2Gt(W077E06)Wrst
B6.129S2-Sesn2Gt(W077E06)Wrst 		decreased lung fibroblast proliferation J:160854
increased cellular sensitivity to hydrogen peroxide J:160854
increased fibroblast apoptosis J:160854
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory