Vgll4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Vgll4
vestigial like family member 4
MGI:2652840

22 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4⁺ C57BL/6N-Vgll4^{tm1b(EUCOMM)Hmgu}/Ieg	decreased locomotor activity	J:211773
	increased bone mineral content	J:211773
	increased circulating lipase level	J:211773
Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1b(EUCOMM)Hmgu} C57BL/6N-Vgll4^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1b(EUCOMM)Hmgu} involves: C57BL/6N * CBA	abnormal blood flow velocity	J:273437
	abnormal heart development	J:273437
	aortic valve stenosis	J:273437
	cardiac hypertrophy	J:273437
	normal cardiovascular system phenotype	J:273437
	decreased body size	J:273437
	decreased body weight	J:273437
	increased cardiac muscle contractility	J:273437
	increased cell proliferation	J:273437
	increased heart weight	J:273437
	premature death	J:273437
	thick aortic valve cusps	J:273437
	thick pulmonary valve cusps	J:273437
Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: C57BL/6J * C57BL/6N * CBA/J * SJL	normal cardiovascular system phenotype	J:273437
Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Tg(Tek-cre)1Ywa/0 involves: C57BL/6N * CBA * SJL	abnormal heart development	J:273437
	cardiac fibrosis	J:273437
	cardiac hypertrophy	J:273437
	normal cardiovascular system phenotype	J:273437
	decreased apoptosis	J:273437
	decreased cardiac muscle contractility	J:273437
	increased cell proliferation	J:273437
	increased heart left ventricle weight	J:273437
	increased heart weight	J:273437
	increased myocardial fiber size	J:273437
	thick aortic valve cusps	J:273437
	thick pulmonary valve cusps	J:273437

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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