Nlrp3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nlrp3
NLR family, pyrin domain containing 3
MGI:2653833

18 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Del(13Naip1-Naip5)1Vnce/Del(13Naip1-Naip5)1Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd involves: C57BL/6J * C57BL/6N	decreased inflammatory response	J:294930
	decreased lactate dehydrogenase level	J:294930
Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp3^tm1Hhf/Nlrp3⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129 * C57BL/6	normal mortality/aging	J:150054
	skin inflammation	J:150054
Mefv^{tm5.1(MEFV)Chae}/Mefv^{tm5.1(MEFV)Chae} Nlrp3^tm1Tsc/Nlrp3^tm1Tsc involves: 129S6/SvEvTac * C57BL/6	decreased body weight	J:172117
	increased inflammatory response	J:172117
	increased interleukin-1 beta secretion	J:172117
Nlrc4^em1Vnce/Nlrc4^em1Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd involves: C57BL/6J * C57BL/6N	decreased inflammatory response	J:294930
	decreased lactate dehydrogenase level	J:294930
Nlrc4^em2Vnce/Nlrc4^em2Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd involves: C57BL/6J * C57BL/6N	decreased inflammatory response	J:294930
	decreased lactate dehydrogenase level	J:294930
Nlrc4^tm1Vmd/Nlrc4^tm1Vmd Nlrp3^tm1Vmd/Nlrp3^tm1Vmd C57BL/6-Nlrp3^tm1Vmd Nlrc4^tm1Vmd	decreased interleukin-1 beta secretion	J:160545
Nlrp3^tm1Flv/Nlrp3^tm1Flv Slc11a1^s/Slc11a1^s B6.129S5-Nlrp3^tm1Flv	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Nlrp3^tm1Hhf/Nlrp3⁺ Rag1^tm1Mom/Rag1^tm1Mom Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129/Sv * 129P2/OlaHsd * C57BL/6	absent B cells	J:150054
	absent T cells	J:150054
	postnatal lethality, complete penetrance	J:150054
	reddish skin	J:150054
	scaly skin	J:150054
	slow postnatal weight gain	J:150054
Nlrp3^tm1Hhf/Nlrp3⁺ Tg(CAG-cre/Esr1)5Amc/? involves: 129/Sv C57BL/6 * CBA	skin inflammation	J:150054
	slow postnatal weight gain	J:150054
Nlrp3^tm1Hhf/Nlrp3⁺ Pycard^tm1Flv/Pycard^tm1Flv Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129 * C57BL/6	no abnormal phenotype detected	J:150054
Nlrp3^tm2Hhf/Nlrp3⁺ Tg(CAG-cre/Esr1)5Amc/? involves: 129/Sv C57BL/6 * CBA	skin inflammation	J:150054
	slow postnatal weight gain	J:150054
Nlrp3^tm2Hhf/Nlrp3^tm2Hhf Vsig4^tm1Gne/Vsig4^tm1Gne B6.Cg-Nlrp3^tm2Hhf Vsig4^tm1Gne	decreased susceptibility to experimental autoimmune encephalomyelitis	J:281762

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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