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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
MGI:2659071
43 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
involves: 129P2/OlaHsd * 129S1/Sv 		normal hematopoietic system phenotype J:165879
normal immune system phenotype J:165879
Rapgef2em1(IMPC)H/Rapgef2+
C57BL/6N-Rapgef2em1(IMPC)H/H 		abnormal retina morphology J:211773
decreased exploration in new environment J:211773
increased circulating bilirubin level J:211773
Rapgef2em1(IMPC)H/Rapgef2em1(IMPC)H
C57BL/6N-Rapgef2em1(IMPC)H/H 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
involves: 129S1/Sv 		lethality throughout fetal growth and development, incomplete penetrance J:165879
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal definitive hematopoiesis J:165879
abnormal vascular development J:165879
decreased birth body size J:165879
decreased erythroid progenitor cell number J:165879
lethality throughout fetal growth and development, incomplete penetrance J:165879
pale liver J:165879
pallor J:165879
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * C57BL/6 * CBA 		normal hematopoietic system phenotype J:165879
normal immune system phenotype J:165879
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * FVB/N 		normal hematopoietic system phenotype J:165879
normal immune system phenotype J:165879
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		normal hematopoietic system phenotype J:165879
normal immune system phenotype J:165879
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(VAV1-cre)1Graf/0
involves: 129S1/Sv 		normal hematopoietic system phenotype J:165879
normal immune system phenotype J:165879
Rapgef2tm1.1Tkat/Rapgef2tm1.1Tkat
involves: 129P2/OlaHsd * C57BL/6 		abnormal vascular development J:125199
abnormal vasculogenesis J:125199
abnormal visceral yolk sac blood island morphology J:125199
absent vitelline blood vessels J:125199
anencephaly J:125199
decreased embryo size J:125199
decreased erythrocyte cell number J:125199
delayed embryo turning J:125199
embryonic growth arrest J:125199
embryonic lethality during organogenesis, complete penetrance J:125199
enlarged allantois J:125199
incomplete embryo turning J:125199
pale yolk sac J:125199
small placenta J:125199
spina bifida J:125199
wavy neural tube J:125199
Rapgef2tm1.2Hous/Rapgef2tm1.2Hous
involves: 129S1/Sv 		abnormal brain development J:165879
abnormal cell adhesion J:165879
abnormal cell migration J:165879
abnormal digestive system development J:165879
abnormal embryonic hematopoiesis J:165879
abnormal erythropoiesis J:165879
abnormal heart development J:165879
abnormal hematopoietic stem cell physiology J:165879
abnormal liver development J:165879
abnormal vascular development J:165879
absent erythrocytes J:165879
absent vitelline blood vessels J:165879
decreased cell proliferation J:165879
decreased common myeloid progenitor cell number J:165879
decreased embryo size J:165879
decreased erythroid progenitor cell number J:165879
decreased hematopoietic stem cell number J:165879
embryonic lethality during organogenesis, complete penetrance J:165879
translucent skin J:165879
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory