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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mir146
microRNA 146
MGI:2676831
55 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mir146tm1.1Bal/Mir146tm1.1Bal
involves: C57BL/6 		abnormal bone marrow cell morphology/development J:173230
abnormal lymphopoiesis J:167922
abnormal regulatory T cell physiology J:167922
anemia J:173230
decreased erythrocyte cell number J:173230
decreased hematocrit J:173230
decreased hemoglobin content J:173230
decreased interferon-gamma secretion J:167922
decreased leukocyte cell number J:173230
decreased lymphocyte cell number J:173230
decreased monocyte cell number J:173230
enlarged spleen J:173230
extramedullary hematopoiesis J:173230
increased B cell derived lymphoma incidence J:173230
increased bone marrow cell number J:173230
increased follicular lymphoma incidence J:173230
increased myeloid sarcoma incidence J:173230
increased regulatory T cell number J:167922
increased spleen neoplasm incidence J:173230
increased spleen weight J:173230
increased T cell derived lymphoma incidence J:173230
myelofibrosis J:173230
myeloid hyperplasia J:167922, J:173230
premature death J:173230
thrombocytopenia J:173230
Mir146tm1.1Bal/Mir146tm1.1Bal
involves: C57BL/6 * FVB/N 		abnormal immune system physiology J:173671
abnormal immune tolerance J:173671
abnormal macrophage physiology J:173671
abnormal T cell activation J:173671
increased circulating interleukin-1 beta level J:173671
increased circulating interleukin-6 level J:173671
increased circulating interleukin-10 level J:173671
increased circulating tumor necrosis factor level J:173671
increased interleukin-1 beta secretion J:173671
increased interleukin-6 secretion J:173671
increased macrophage nitric oxide production J:173671
increased susceptibility to bacterial infection induced morbidity/mortality J:173671
increased susceptibility to endotoxin shock J:173671
increased tumor necrosis factor secretion J:173671
myeloid hyperplasia J:173671
premature death J:173671
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 		increased germinal center B cell number J:266124
increased T follicular helper cell number J:266124
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(CD2-icre)4Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca 		increased germinal center B cell number J:266124
increased T follicular helper cell number J:266124
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		normal immune system phenotype J:266124
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(Cr2-cre)3Cgn/0
involves: C57BL/6 		increased anti-double stranded DNA antibody level J:266124
increased germinal center B cell number J:266124
increased IgG1 level J:266124
increased IgG level J:266124
increased plasma cell number J:266124
increased T follicular helper cell number J:266124
Mir146tm1.1Mtm/Mir146tm1.1Mtm
involves: 129P2/OlaHsd * C57BL/6 * FVB 		normal mortality/aging J:181831
Mir146tm2.1Bal/Mir146tm2.1Bal
involves: 129S1/Sv * C57BL/6 * FVB/N 		abnormal bone marrow cell physiology J:173671
abnormal immune system physiology J:173671
abnormal immune tolerance J:173671
abnormal macrophage physiology J:173671
abnormal spleen B cell follicle morphology J:173671
abnormal T cell activation J:173671
anemia J:173671
decreased hematocrit J:173671
decreased hemoglobin content J:173671
decreased lymphocyte cell number J:173671
decreased monocyte cell number J:173671
enlarged lymph nodes J:173671
enlarged spleen J:173671
extramedullary hematopoiesis J:173671
normal immune system phenotype J:173671
increased acute inflammation J:173671
increased anti-double stranded DNA antibody level J:173671
increased circulating interleukin-1 beta level J:173671
increased circulating interleukin-6 level J:173671
increased circulating interleukin-10 level J:173671
increased circulating tumor necrosis factor level J:173671
increased follicular lymphoma incidence J:173671
increased hemolymphoid system tumor incidence J:173671
increased interleukin-1 beta secretion J:173671
increased interleukin-6 secretion J:173671
increased macrophage nitric oxide production J:173671
increased spleen germinal center number J:173671
increased spleen germinal center size J:173671
increased spleen weight J:173671
increased susceptibility to bacterial infection induced morbidity/mortality J:173671
increased susceptibility to endotoxin shock J:173671
increased tumor incidence J:173671
increased tumor necrosis factor secretion J:173671
myeloid hyperplasia J:173671
premature death J:173671
thrombocytopenia J:173671
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory