Mir155 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mir155
microRNA 155
MGI:2676840

66 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(Mirn155)Rsky}/Gt(ROSA)26Sor^{tm1(Mirn155)Rsky} involves: BALB/c * C57BL/6	abnormal humoral immune response	J:121084
	increased germinal center B cell number	J:121084
	normal reproductive system phenotype	J:121084
Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wmz/0 involves: 129 * C57BL/6 * FVB/N * SJL/J	abnormal coat appearance	J:185598
	abnormal immune system morphology	J:185598
	ataxia	J:185598
	enlarged liver	J:185598
	enlarged lymph nodes	J:185598
	enlarged spleen	J:185598
	hindlimb paresis	J:185598
	hunched posture	J:185598
	increased apoptosis	J:185598
	increased B cell derived lymphoma incidence	J:185598
	increased spleen weight	J:185598
	increased spleen white pulp amount	J:185598
	normal nervous system phenotype	J:185598
	premature death	J:185598
	respiratory distress	J:185598
	thymus hyperplasia	J:185598
	tumor regression	J:185598
Mir155^tm1.1Brd/Mir155^tm1.1Brd B6.129S7-Mir155^tm1.1Brd	decreased regulatory T cell number	J:146268
Mir155^tm1.1Brd/Mir155^tm1.1Brd B6.Cg-Mir155^tm1.1Brd Tyr^c-Brd	abnormal CD4-positive, alpha beta T cell morphology	J:121095
	abnormal CD4-positive, alpha-beta T cell physiology	J:121095
	abnormal dendritic cell physiology	J:121095
	abnormal T-helper 1 cell morphology	J:121095
	decreased IgG1 level	J:121095
	normal immune system phenotype	J:121095
	increased susceptibility to bacterial infection	J:121095
	increased T-helper 2 cell number	J:121095
Mir155^tm1.1Ggard/Mir155^tm1.1Ggard involves: C57BL/6	no abnormal phenotype detected	J:218084
Mir155^tm1.1Rsky/Mir155^tm1.1Rsky B6.Cg-Mir155^tm1Rsky/J	abnormal T cell physiology	J:226678
	abnormal T-helper 17 cell differentiation	J:226678
	decreased effector memory T-helper cell number	J:226678
	decreased interleukin-6 secretion	J:226678
	decreased regulatory T cell number	J:226678
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:226678
	decreased T-helper 17 cell number	J:226678
Mir155^tm1.1Rsky/Mir155^tm1.1Rsky involves: 129 * C57BL/6	abnormal B cell physiology	J:121084
	abnormal cytokine secretion	J:121084
	abnormal germinal center B cell physiology	J:121084
	abnormal humoral immune response	J:121084
	abnormal T cell physiology	J:121084
	decreased germinal center B cell number	J:121084
Mir155^tm1Brd/Mir155^tm1Brd involves: 129S7/SvEvBrd * C57BL/6	abnormal B cell physiology	J:121095
	abnormal bronchiole morphology	J:121095
	abnormal class switch recombination	J:121095
	abnormal cytokine secretion	J:121095
	abnormal lung morphology	J:121095
	decreased IgM level	J:121095
	normal immune system phenotype	J:121095
	intestinal inflammation	J:121095
	lung inflammation	J:121095
Mir155^tm1Rsky/Mir155^tm1Rsky involves: 129 * C57BL/6	abnormal class switch recombination	J:136224
Mir155^tm1Rsky/Mir155^tm1Rsky involves: 129 * C57BL/6	chromosomal instability	J:136224
Mir155^tm1Rsky/Mir155^tm1Rsky involves: 129/Sv * C57BL/6	abnormal cytokine secretion	J:121084
	abnormal gut-associated lymphoid tissue morphology	J:121084
	abnormal humoral immune response	J:121084
	abnormal immune system morphology	J:121084
	abnormal immune system physiology	J:121084
	abnormal Peyer's patch germinal center morphology	J:121084
	decreased interferon-gamma secretion	J:121084
	decreased interleukin-4 secretion	J:121084
	decreased spleen germinal center number	J:121084
	decreased spleen germinal center size	J:121084
	decreased tumor necrosis factor secretion	J:121084
	increased interleukin-10 secretion	J:121084
Tg(Igh-Mir155)8Cro/0 involves: FVB/N	abnormal lymphopoiesis	J:109591
	abnormal spleen B cell follicle morphology	J:109591
	decreased leukocyte cell number	J:109591
	decreased spleen white pulp amount	J:109591
	enlarged spleen	J:109591
	extramedullary hematopoiesis	J:109591
	increased B cell derived lymphoma incidence	J:109591
	increased B cell number	J:109591
	increased B cell proliferation	J:109591
	increased lymphoblastic lymphoma incidence	J:109591
	increased pre-B cell number	J:109591
	increased spleen white pulp amount	J:109591
	intermingled spleen red and white pulp	J:109591
Tg(Igh-Mir155)10Cro/0 involves: FVB/N	enlarged spleen	J:109591

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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