Mir22 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mir22
microRNA 22
MGI:2676896

27 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a1^{tm1(CAG-Mir22)Ppp}/Col1a1^{tm1(CAG-Mir22)Ppp} Tg(Mx1-cre)1Cgn/0 Not Specified	abnormal erythropoiesis	J:199366
	abnormal hematopoietic system morphology/development	J:199366
	anemia	J:199366
	decreased leukocyte cell number	J:199366
	enlarged spleen	J:199366
	increased hematopoietic stem cell number	J:199366
	increased leukemia incidence	J:199366
	increased myeloid dendritic cell number	J:199366
	increased T cell derived lymphoma incidence	J:199366
Mir22^tm1.1Arod/Mir22^tm1.1Arod involves: 129S1/SvImJ * 129S7/SvEvBrd	abnormal cardiovascular system physiology	J:183005
	cardiac fibrosis	J:183005
	normal cardiovascular system phenotype	J:183005
	congestive heart failure	J:183005
	decreased cardiac muscle contractility	J:183005
	dilated heart ventricle	J:183005
	increased physiological sensitivity to xenobiotic	J:183005
Mir22^tm1.2Dzw/Mir22^tm1.2Dzw involves: C57BL/6	normal cardiovascular system phenotype	J:213308
	decreased response of heart to induced stress	J:213308
	increased response of heart to induced stress	J:213308
Mir22^tm1Boet/Mir22^tm1Boet B6.129S2-Mir22^tm1Boet	normal behavior/neurological phenotype	J:266382
	decreased body weight	J:266382
	decreased circulating free fatty acids level	J:266382
	decreased circulating leptin level	J:266382
	decreased white adipose tissue amount	J:266382
	decreased white fat cell size	J:266382
	normal homeostasis/metabolism phenotype	J:266382
	increased fatty acid oxidation	J:266382
	normal muscle phenotype	J:266382

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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