Crb2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Crb2
crumbs family member 2
MGI:2679260

61 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Crb2^tm1.1Wij/Crb2⁺ Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	normal vision/eye phenotype	J:191149
Crb2^tm1.1Wij/Crb2^tm1.1Wij involves: 129P2/OlaHsd * 129S4/SvJaeSor	no abnormal phenotype detected	J:191149
Crb2^tm1.1Wij/Crb2^tm1.1Wij involves: 129P2/OlaHsd * C57BL/6J	abnormal retina layer morphology	J:210675
	abnormal retina outer plexiform layer morphology	J:210675
Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	abnormal cone electrophysiology	J:191149
	abnormal eye electrophysiology	J:191149
	abnormal retina bipolar cell morphology	J:191149
	abnormal retina blood vessel morphology	J:191149
	abnormal retina cone cell morphology	J:191149
	abnormal retina layer morphology	J:191149
	abnormal retina morphology	J:191149
	abnormal retina neuronal layer morphology	J:191149
	abnormal retina outer limiting membrane morphology	J:191149
	abnormal retina photoreceptor layer morphology	J:191149
	abnormal retina pigment epithelium morphology	J:191149
	abnormal rod electrophysiology	J:191149
	decreased retina photoreceptor cell number	J:191149
	increased susceptibility to age-related retinal degeneration	J:191149
	thin retina outer nuclear layer	J:191149
Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Crx-cre)1Tfur/0 involves: 129P2/OlaHsd * C57BL/6J	abnormal electroretinogram waveform feature	J:210675
	abnormal Muller cell morphology	J:210675
	abnormal ocular fundus morphology	J:210675
	abnormal retina cone cell outer segment morphology	J:210675
	abnormal retina ganglion layer morphology	J:210675
	abnormal retina layer morphology	J:210675
	abnormal retina morphology	J:210675
	abnormal retina outer limiting membrane morphology	J:210675
	abnormal retina outer nuclear layer morphology	J:210675
	abnormal retina outer plexiform layer morphology	J:210675
	abnormal retina photoreceptor layer morphology	J:210675
	abnormal retina pigment epithelium morphology	J:210675
	decreased a-wave amplitude	J:210675
	dilated brain ventricle	J:210675
	hydrocephaly	J:210675
	increased susceptibility to age-related retinal degeneration	J:210675
	retina fold	J:210675
	retina neovascularization	J:210675
	short retina cone cell outer segment	J:210675
	short retina rod cell outer segment	J:210675
	thin retina outer nuclear layer	J:210675
Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Pdgfra-cre)1Clc/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	abnormal retina layer morphology	J:210675
	abnormal retina outer limiting membrane morphology	J:210675
	abnormal retina outer nuclear layer morphology	J:210675
	prenatal lethality, incomplete penetrance	J:210675
	thin retina outer nuclear layer	J:210675
Crb2^{tm1a(KOMP)Wtsi}/Crb2⁺ C57BL/6N-Crb2^{tm1a(KOMP)Wtsi}/Wtsi	abnormal retina morphology	J:211773
	abnormal vibrissa morphology	J:211773
Crb2^{tm1a(KOMP)Wtsi}/Crb2^{tm1a(KOMP)Wtsi} C57BL/6N-Crb2^{tm1a(KOMP)Wtsi}/Wtsi	abnormal chorion morphology	J:261316
	abnormal placenta morphology	J:261316
	abnormal visceral yolk sac morphology	J:261316
	embryonic lethality during organogenesis, complete penetrance	J:261316
	preweaning lethality, complete penetrance	J:211773
Crb2^tm1Vlcg/Crb2^tm1Vlcg B6.Cg-Crb2^tm1Vlcg	abnormal anterior primitive streak morphology	J:177837
	abnormal chorioallantoic fusion	J:177837
	abnormal digestive system development	J:177837
	abnormal embryonic epiblast morphology	J:177837
	abnormal embryonic neuroepithelium morphology	J:177837
	abnormal embryonic tissue morphology	J:177837
	abnormal endoderm development	J:177837
	abnormal foregut morphology	J:177837
	abnormal gastrulation	J:177837
	abnormal head fold morphology	J:177837
	abnormal mesoderm development	J:177837
	abnormal notochord morphology	J:177837
	abnormal primitive streak morphology	J:177837
	abnormal somite development	J:177837
	abnormal visceral yolk sac blood island morphology	J:177837
	abnormal vitelline vasculature morphology	J:177837
	absent heart tube	J:177837
	embryonic lethality during organogenesis, complete penetrance	J:177837
	failure of chorioallantoic fusion	J:177837
	failure of initiation of embryo turning	J:177837
	increased embryo size	J:177837
	open neural tube	J:177837
	small allantois	J:177837
	small amniotic cavity	J:177837

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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