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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nlgn2
neuroligin 2
MGI:2681835
38 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nlgn2tm1.1Gchn/Nlgn2tm1.1Gchn
involves: 129S/SvEv * C57BL/6J 		abnormal emotion/affect behavior J:272181
abnormal hippocampus physiology J:272181
abnormal miniature inhibitory postsynaptic currents J:272181
abnormal postsynaptic density morphology J:272181
abnormal spatial working memory J:272181
decreased freezing behavior J:272181
decreased miniature inhibitory postsynaptic current amplitude J:272181
decreased miniature inhibitory postsynaptic current frequency J:272181
decreased prepulse inhibition J:272181
decreased startle reflex J:272181
impaired contextual conditioning behavior J:272181
increased circulating corticosterone level J:272181
increased thigmotaxis J:272181
induced hyperactivity J:272181
Nlgn2tm1.1Sud/Nlgn2tm1.1Sud
involves: C57BL/6NTac 		abnormal CNS synaptic transmission J:229887
abnormal inhibitory postsynaptic currents J:229887
abnormal miniature inhibitory postsynaptic currents J:229887
abnormal synapse morphology J:229887
normal behavior/neurological phenotype J:229887
decreased anxiety-related response J:229887
decreased miniature inhibitory postsynaptic current amplitude J:229887
decreased miniature inhibitory postsynaptic current frequency J:229887
impaired contextual conditioning behavior J:229887
impaired cued conditioning behavior J:229887
social withdrawal J:229887
Nlgn2tm1.1Sud/Nlgn2tm1.1Sud
Tg(Pcp2-cre)2Mpin/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		abnormal inhibitory postsynaptic currents J:227671
decreased miniature inhibitory postsynaptic current frequency J:227671
increased excitatory postsynaptic current amplitude J:227671
normal nervous system phenotype J:227671
Tg(Thy1-Nlgn2)6Hnes/0
involves: C57BL/6 * CBA 		abnormal brain morphology J:137376
abnormal brain wave pattern J:137376
abnormal response to novelty J:137376
abnormal social investigation J:137376
normal behavior/neurological phenotype J:137376
hyperactivity J:137376
increased anxiety-related response J:137376
increased miniature inhibitory postsynaptic current frequency J:137376
increased startle reflex J:137376
increased stereotypic behavior J:137376
increased thigmotaxis J:137376
increased vertical activity J:137376
kyphosis J:137376
limb grasping J:137376
normal nervous system phenotype J:137376
premature death J:137376
slow postnatal weight gain J:137376
straub tail J:137376
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory