Zfat Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Zfat
zinc finger and AT hook domain containing
MGI:2681865

26 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Zfat^{em1(IMPC)Ccpcz}/Zfat⁺ C57BL/6NCrl-Zfat^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	abnormal tooth morphology	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
Zfat^{em1(IMPC)Ccpcz}/Zfat^{em1(IMPC)Ccpcz} C57BL/6NCrl-Zfat^{em1(IMPC)Ccpcz}/Ccpcz	abnormal embryo size	J:211773
	embryonic growth retardation	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Zfat^tm1Sawa/Zfat^tm1Sawa B6.Cg-Zfat^tm1Sawa	abnormal embryonic hematopoiesis	J:163605
	abnormal spongiotrophoblast layer morphology	J:163605
	abnormal visceral yolk sac blood island morphology	J:163605
	embryonic lethality, complete penetrance	J:163605
	failure of initiation of embryo turning	J:163605
	pale yolk sac	J:163605
Zfat^tm2.1Sawa/Zfat^tm2.1Sawa Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * C57BL/6JJcl * C57BL/6NCrSlc * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:187164
	abnormal CD8-positive, alpha-beta T cell differentiation	J:187164
	decreased CD4-positive, alpha-beta T cell number	J:187164
	decreased CD8-positive, alpha-beta T cell number	J:187164
	decreased interleukin-2 secretion	J:187164
	decreased T cell proliferation	J:187164
	normal immune system phenotype	J:187164
	increased T cell apoptosis	J:187164
Zfat^tm3.1Sawa/Zfat^tm3.1Sawa B6.Cg-Zfat^tm3.1Sawa	prenatal lethality, complete penetrance	J:270991

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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