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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kmt2d
lysine (K)-specific methyltransferase 2D
MGI:2682319
91 phenotypes from 5 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Kmt2dtm2.1Kaig/Kmt2d+
involves: C57BL/6J * CBA/J 		abnormal ear shape J:294895
abnormal presphenoid bone morphology J:294895
abnormal snout morphology J:294895
broad face J:294895
domed cranium J:294895
postnatal growth retardation J:294895
short nasal bone J:294895
small basisphenoid bone J:294895
small presphenoid bone J:294895
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Kmt2dtm2.1Kaig/Kmt2dtm2.1Kaig
involves: C57BL/6J * CBA/J 		abnormal basisphenoid bone morphology J:294895
abnormal chondrocyte morphology J:294895
abnormal cranial neural crest cell morphology J:294895
abnormal endochondral bone ossification J:294895
abnormal hyoid bone morphology J:294895
abnormal neurocranium morphology J:294895
abnormal osteoblast morphology J:294895
abnormal palatal shelf morphology J:294895
abnormal palatine bone morphology J:294895
abnormal presphenoid bone morphology J:294895
abnormal pterygoid process morphology J:294895
abnormal temporal bone tympanic part morphology J:294895
abnormal viscerocranium morphology J:294895
cleft palate J:294895
face hypoplasia J:294895
glossoptosis J:294895
mandible hypoplasia J:294895
mandibular condyloid process hypoplasia J:294895
neonatal lethality, complete penetrance J:294895
short frontal bone J:294895
short nasal bone J:294895
small basisphenoid bone J:294895
small presphenoid bone J:294895
Kmt2dbapa/Kmt2dbapa
BALB/cJ-Kmt2dbapa 		abnormal gait J:290290
abnormal motor capabilities/coordination/movement J:290290
abnormal pinna reflex J:290290
decreased coping response J:290290
hyporesponsive to tactile stimuli J:290290
impaired coordination J:290290
impaired righting response J:290290
increased grooming behavior J:290290
increased locomotor activity J:290290
increased vertical activity J:290290
limb grasping J:227974
short stride length J:290290
Kmt2dGt(RRT024)Byg/Kmt2d+
involves: 129P2/OlaHsd 		decreased body fat mass J:301497
decreased body length J:301083
decreased body size J:301083
decreased body weight J:301083, J:301497
decreased neuron number J:301083
decreased susceptibility to diet-induced obesity J:301497
improved glucose tolerance J:301497
increased bile salt level J:301497
increased insulin sensitivity J:301497
Kmt2dGt(RRT024)Byg/Kmt2d+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal dentate gyrus morphology J:225779
abnormal hippocampus granule cell layer J:225779
abnormal inner ear canal morphology J:225779
abnormal object recognition memory J:225779
decreased body weight J:225779
flattened snout J:225779
impaired contextual conditioning behavior J:225779
impaired spatial learning J:225779
short maxilla J:225779
Kmt2dGt(RRT024)Byg/Kmt2dGt(RRT024)Byg
involves: 129P2/OlaHsd 		embryonic lethality prior to organogenesis J:301497
Kmt2dGt(RRT024)Byg/Kmt2dGt(RRT024)Byg
involves: 129P2/OlaHsd * C57BL/6J 		embryonic lethality during organogenesis, complete penetrance J:225779
Kmt2dGt(XT0709)Wtsi/Kmt2dGt(XT0709)Wtsi
involves: 129P2/OlaHsd 		embryonic lethality during organogenesis, complete penetrance J:207891
Kmt2dtm1.1Kaig/Kmt2d+
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 		increased germinal center B cell number J:228913
increased spleen germinal center size J:228913
Kmt2dtm1.1Kaig/Kmt2d+
Tmem163Tg(ACTB-cre)2Mrt/0
B6.Cg-Kmt2dtm1.1Kaig Tg(ACTB-cre)2Mrt 		abnormal heart echocardiography feature J:229890
normal cardiovascular system phenotype J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:228913
decreased B cell number J:228913
decreased follicular B cell number J:228913
decreased IgG1 level J:228913
decreased IgM level J:228913
decreased mature B cell number J:228913
normal immune system phenotype J:228913
increased B cell proliferation J:228913
increased germinal center B cell number J:228913
increased spleen germinal center number J:228913
increased spleen germinal center size J:228913
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:228913
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Mesp1tm2(cre)Ysa/Mesp1+
B6.Cg-Mesp1tm2(cre)Ysa Kmt2dtm1.1Kaig 		abnormal heart tube morphology J:229890
embryonic growth retardation J:229890
embryonic lethality during organogenesis, complete penetrance J:229890
pericardial edema J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Myf5tm3(cre)Sor/Myf5+
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal brown fat cell differentiation J:207891
abnormal muscle morphology J:207891
decreased brown adipose tissue amount J:207891
decreased muscle weight J:207891
neonatal lethality, complete penetrance J:207891
respiratory failure J:207891
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tg(Mef2c-cre)2Blk/0
B6.Cg-Kmt2dtm1.1Kaig Tg(Mef2c-cre)2Blk 		abnormal interventricular septum morphology J:229890
embryonic lethality during organogenesis, complete penetrance J:229890
persistent truncus arteriosus J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tg(Nkx2-1-cre)2Sand/0
involves: C57BL/6 		decreased circulating glucose level J:301083
decreased neuron number J:301083
impaired neuron differentiation J:301083
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tg(Tnnt2-cre)5Blh/0
B6.Cg-Kmt2dtm1.1Kaig Tg(Tnnt2-cre)5Blh 		abnormal fetal cardiomyocyte physiology J:229890
abnormal interventricular septum morphology J:229890
normal cardiovascular system phenotype J:229890
decreased fetal cardiomyocyte proliferation J:229890
embryonic lethality during organogenesis, complete penetrance J:229890
thin myocardium compact layer J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tmem163Tg(ACTB-cre)2Mrt/0
B6.Cg-Kmt2dtm1.1Kaig Tg(ACTB-cre)2Mrt 		absent head fold J:229890
absent somites J:229890
embryonic lethality between somite formation and embryo turning, complete penetrance J:229890
Kmt2dtm2.1Kaig/Kmt2dtm2.1Kaig
Tg(Sox10-cre)1Wdr/0
involves: C57BL/6 * C57BL/6J * CBA 		abnormal basicranium morphology J:294895
face hypoplasia J:294895
mandible hypoplasia J:294895
short frontal bone J:294895
short nasal bone J:294895
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory