Dhps Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dhps
deoxyhypusine synthase
MGI:2683592

15 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dhps^{Gt(RRM039)Byg}/Dhps^{Gt(RRM039)Byg} involves: 129P2/OlaHsd * C57BL/6J	abnormal preimplantation embryo development	J:285882
	decreased cell proliferation	J:285882
	embryonic lethality between implantation and somite formation, complete penetrance	J:285882
Dhps^tm1Itl/Dhps⁺ involves: 129S/SvEv * C57BL/6	no abnormal phenotype detected	J:232390
Dhps^tm1Itl/Dhps^tm1Itl involves: 129S/SvEv * C57BL/6	embryonic lethality, complete penetrance	J:232390
Dhps^{tm2a(EUCOMM)Wtsi}/Dhps⁺ C57BL/6N-Dhps^{tm2a(EUCOMM)Wtsi}/Wtsi	increased hemoglobin content	J:211773
Dhps^{tm2a(EUCOMM)Wtsi}/Dhps^{tm2a(EUCOMM)Wtsi} C57BL/6N-Dhps^{tm2a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
Dhps^{tm2c(EUCOMM)Wtsi}/Dhps^{tm2c(EUCOMM)Wtsi} Tg(CAG-cre/Esr1)5Amc/0 involves: C57BL/6J C57BL/6N * CBA * SJL	cachexia	J:236582
	decreased body weight	J:236582
	decreased bone marrow cell number	J:236582
	decreased spleen red pulp amount	J:236582
	increased kidney iron level	J:236582
	premature death	J:236582
	spleen hypoplasia	J:236582
Dhps^{tm2d(EUCOMM)Wtsi}/Dhps^{tm2d(EUCOMM)Wtsi} involves: BALB/cJ * C57BL/6J * C57BL/6N * SJL	prenatal lethality, complete penetrance	J:236582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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