Kcnh6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kcnh6
potassium voltage-gated channel, subfamily H (eag-related), member 6
MGI:2684139

25 phenotypes from 3 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kcnh6^em1Jkya/Kcnh6^em1Jkya involves: C57BL/6N	abnormal action potential	J:271003
	abnormal calcium ion homeostasis	J:271003
	abnormal glucose homeostasis	J:271003
	abnormal insulin secretion	J:271003
	abnormal pancreatic beta cell physiology	J:271003
	decreased channel response intensity	J:271003
	decreased circulating glucose level	J:271003
	decreased circulating insulin level	J:271003
	decreased insulin secretion	J:271003
	decreased pancreatic beta cell mass	J:271003
	decreased pancreatic beta cell number	J:271003
	impaired glucose tolerance	J:271003
	increased circulating insulin level	J:271003
	increased endoplasmic reticulum stress	J:271003
	increased fasting circulating glucose level	J:271003
	increased insulin secretion	J:271003
	increased pancreatic alpha cell number	J:271003
	increased pancreatic islet cell apoptosis	J:271003
	pancreas necrosis	J:271003
Kcnh6^em2Jkya/Kcnh6^em2Jkya involves: C57BL/6N	abnormal action potential	J:271003
	abnormal glucose homeostasis	J:271003
	abnormal pancreatic beta cell physiology	J:271003
	decreased channel response intensity	J:271003
	decreased circulating glucose level	J:271003
	decreased circulating insulin level	J:271003
	decreased insulin secretion	J:271003
	impaired glucose tolerance	J:271003
	increased circulating insulin level	J:271003
	increased fasting circulating glucose level	J:271003
Kcnh6^{tm1.1(KOMP)Vlcg}/Kcnh6^{tm1.1(KOMP)Vlcg} C57BL/6N-Kcnh6^{tm1.1(KOMP)Vlcg}/Tcp	abnormal kidney morphology	J:211773
	abnormal skin morphology	J:211773
	enlarged kidney	J:211773
	increased circulating calcium level	J:211773
	increased circulating serum albumin level	J:211773
	increased circulating total protein level	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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