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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nlrp1a
NLR family, pyrin domain containing 1A
MGI:2684861
32 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nlrp1aem1(IMPC)Mbp/Nlrp1aem1(IMPC)Mbp
C57BL/6N-Nlrp1aem1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
microphthalmia J:211773
Nlrp1am1Btlr/Nlrp1am1Btlr
C57BL/6J-Nlrp1am1Btlr 		decreased B cell number J:265173
decreased B-1 B cell number J:265173
decreased B-1b cell number J:265173
decreased B-2 B cell number J:265173
decreased body weight J:265173
decreased CD8-positive, alpha-beta T cell number J:265173
decreased central memory CD8 positive, alpha-beta T cell number J:265173
decreased NK cell number J:265173
decreased single-positive T cell number J:265173
decreased T cell number J:265173
increased effector memory CD8-positive, alpha-beta T cell number J:265173
increased IgE level J:265173
increased macrophage apoptosis J:265173
increased tumor necrosis factor secretion J:265173
Nlrp1am2Btlr/Nlrp1am2Btlr
C57BL/6J-Nlrp1am2Btlr 		decreased B cell number J:265174
decreased interleukin-1 beta secretion J:265174
decreased NK cell number J:265174
hypoglycemia J:265174
increased dendritic cell number J:265174
increased macrophage apoptosis J:265174
increased neutrophil cell number J:265174
Nlrp1aNeut1/Nlrp1a+
C.B6-Nlrp1aNeut1 		increased inflammatory response J:191055
liver inflammation J:191055
lung inflammation J:191055
meningitis J:191055
myocarditis J:191055
pancreas inflammation J:191055
normal reproductive system phenotype J:191055
Nlrp1aNeut1/Nlrp1aNeut1
C.B6-Nlrp1aNeut1 		decreased lymphocyte cell number J:191055
decreased macrophage cell number J:191055
enlarged spleen J:191055
increased inflammatory response J:191055
increased macrophage cytokine production J:191055
increased neutrophil cell number J:191055
liver inflammation J:191055
lung inflammation J:191055
meningitis J:191055
myocarditis J:191055
pancreas inflammation J:191055
premature death J:191055
normal reproductive system phenotype J:191055
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory