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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kalrn
kalirin, RhoGEF kinase
MGI:2685385
44 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kalrntm1.1Npl/Kalrntm1.1Npl
involves: 129S1/Sv * C57BL/6 		abnormal action potential J:142364
abnormal contextual conditioning behavior J:142364
abnormal dendrite morphology J:142364
abnormal hippocampus pyramidal cell morphology J:142364
abnormal neuron physiology J:142364
normal behavior/neurological phenotype J:142364
decreased anxiety-related response J:142364
decreased CNS synapse formation J:142364
decreased excitatory postsynaptic current frequency J:142364
reduced long-term potentiation J:142364
Kalrntm1.1Npl/Kalrntm1.1Npl
Not Specified 		enhanced coordination J:206512
Kalrntm1Ppen/Kalrn+
Not Specified 		increased locomotor activity J:152011
Kalrntm1Ppen/Kalrntm1Ppen
Not Specified 		abnormal cerebral cortex pyramidal cell morphology J:152011
abnormal social/conspecific interaction behavior J:152011
abnormal spatial working memory J:152011
decreased miniature excitatory postsynaptic current frequency J:152011
decreased physiological sensitivity to xenobiotic J:152011
decreased prepulse inhibition J:152011
hyperactivity J:152011
reduced AMPA-mediated synaptic currents J:152011
Kalrntm2.1Npl/Kalrn+
B6.Cg-Kalrntm2.1Npl 		impaired coordination J:206512
impaired passive avoidance behavior J:206512
Kalrntm2.1Npl/Kalrntm2.1Npl
B6.Cg-Kalrntm2.1Npl 		abnormal behavior J:206512
abnormal I band morphology J:206512
abnormal maternal behavior J:206512
abnormal milk ejection J:206512
abnormal nest building behavior J:206512
abnormal neuromuscular synapse morphology J:206512
abnormal pituitary secretion J:206512
abnormal sarcomere morphology J:206512
abnormal Z line morphology J:206512
acromegaly J:206512
normal behavior/neurological phenotype J:206512
normal cardiovascular system phenotype J:206512
decreased anxiety-related response J:206512
decreased body size J:206512
decreased body weight J:206512
decreased startle reflex J:206512
normal homeostasis/metabolism phenotype J:206512
impaired coordination J:206512
impaired passive avoidance behavior J:206512
normal mortality/aging J:206512
normal nervous system phenotype J:206512
parturition failure J:206512
postnatal growth retardation J:206512
pregnancy-related premature death J:206512
Kalrntm2.1Npl/Kalrntm2.1Npl
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 		preweaning lethality, incomplete penetrance J:206512
Kalrntm2Npl/Kalrntm2Npl
B6.Cg-Kalrntm2Npl 		no abnormal phenotype detected J:206512
Kalrntm2Npl/Kalrntm2Npl
Tg(Nes-cre)1Kln/0
B6.Cg-Kalrntm2Npl Tg(Nes-cre)1Kln 		impaired coordination J:206512
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory