Klhl6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Klhl6
kelch-like 6
MGI:2686922

38 phenotypes from 12 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Klhl6^tm2Sato/Klhl6^tm2Sato either: (involves: 129P2/OlaHsd * 129T2/SvEms) or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * CD-1)	abnormal B cell differentiation	J:101363
	abnormal lymph node germinal center morphology	J:101363
	decreased B cell number	J:101363
Klhl6^{em1(IMPC)Ccpcz}/Klhl6^{em1(IMPC)Ccpcz} C57BL/6NCrl-Klhl6^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal inspiratory capacity	J:211773
	abnormal kidney morphology	J:211773
	abnormal lung morphology	J:211773
	abnormal pancreas morphology	J:211773
	abnormal seminal vesicle morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal thymus morphology	J:211773
	decreased effector memory T-helper cell number	J:211773
	enlarged heart	J:211773
	enlarged kidney	J:211773
	enlarged pancreas	J:211773
	enlarged thymus	J:211773
	increased CD4-positive, alpha-beta T cell number	J:211773
	increased CD8-positive, alpha-beta T cell number	J:211773
	increased CD8-positive, naive alpha-beta T cell number	J:211773
	increased T cell number	J:211773
	increased T-helper cell number	J:211773
	small seminal vesicle	J:211773
	small spleen	J:211773
	small testis	J:211773
Klhl6^m1Anu/Klhl6^m1Anu C57BL/6JAnu-Klhl6^m1Anu	decreased B cell number	J:104190
	decreased mature B cell number	J:104190
	increased immature B cell number	J:104190
Klhl6^m1Btlr/Klhl6^m1Btlr C57BL/6J-Klhl6^m1Btlr	decreased B cell number	J:265167
	decreased central memory CD4-positive, alpha-beta T cell number	J:265167
	increased B-1b cell number	J:265167
	increased CD4-positive, alpha-beta T cell number	J:265167
	increased single-positive T cell number	J:265167
	increased T cell number	J:265167
Klhl6^m2Btlr/Klhl6^m2Btlr C57BL/6J-Klhl6^m2Btlr	decreased CD8-positive, alpha-beta T cell number	J:265168
	increased CD4-positive, alpha-beta T cell number	J:265168
	increased single-positive T cell number	J:265168
	increased T cell number	J:265168
Klhl6^M3Btlr/Klhl6^M3Btlr C57BL/6J-Klhl6^M3Btlr	increased alpha-beta T cell number	J:267699
	increased B-1a cell number	J:267699
	increased CD4-positive, alpha-beta T cell number	J:267699
	increased CD8-positive, alpha-beta T cell number	J:267699
Klhl6^m4Btlr/Klhl6^m4Btlr C57BL/6J-Klhl6^m4Btlr	increased B-1 B cell number	J:272394
Klhl6^M5Btlr/Klhl6^M5Btlr C57BL/6J-Klhl6^M5Btlr	increased B-1 B cell number	J:272395
Klhl6^m6Btlr/Klhl6^m6Btlr C57BL/6J-Klhl6^m6Btlr	increased alpha-beta T cell number	J:272396
Klhl6^m6Btlr/Klhl6^m6Btlr C57BL/6J-Klhl6^m6Btlr	increased CD4-positive, alpha-beta T cell number	J:272396
Klhl6^M7Btlr/Klhl6^M7Btlr C57BL/6J-Klhl6^M7Btlr	abnormal B cell differentiation	J:272397
Klhl6^M8Btlr/Klhl6^M8Btlr C57BL/6J-Klhl6^M8Btlr	decreased B cell number	J:274963
	increased CD4-positive, alpha-beta T cell number	J:274963
	increased T cell number	J:274963
Klhl6^tm1Sato/Klhl6^tm1Sato either: (involves: 129T2/SvEms) or (involves: BALB/c) or (involves: CD-1)	abnormal adaptive immunity	J:101363
	abnormal B cell differentiation	J:101363
	abnormal lymph node germinal center morphology	J:101363
	abnormal spleen morphology	J:101363
	decreased B cell number	J:101363
	decreased follicular B cell number	J:101363
	decreased spleen weight	J:101363
	spleen hypoplasia	J:101363

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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