Ighg2c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ighg2c
immunoglobulin heavy constant gamma 2C
MGI:2686979

21 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ighg2c^em1Wliu/Ighg2c^em1Wliu C57BL/6J-Ighg2c^em1Wliu	abnormal dendritic cell physiology	J:322180
	abnormal macrophage activation involved in immune response	J:322180
	abnormal macrophage physiology	J:322180
	abnormal plasma cell differentiation	J:322180
	decreased incidence of induced tumors	J:322180
	decreased incidence of tumors by chemical induction	J:322180
	decreased susceptibility to induced colitis	J:322180
	decreased susceptibility to induced morbidity/mortality	J:322180
	decreased tumor growth/size	J:322180
	increased CD8-positive, alpha-beta T cell number	J:322180
	increased CD103-positive CD11b-low dendritic cell number	J:322180
	increased effector memory CD8-positive, alpha-beta T cell number	J:322180
	increased germinal center B cell number	J:322180
	increased IgG2c level	J:322180
	increased memory B cell number	J:322180
Ighg2c^em2Wliu/Ighg2c^em2Wliu C57BL/6J-Ighg2c^em2Wliu	abnormal macrophage activation involved in immune response	J:322180
	abnormal plasma cell differentiation	J:322180
	decreased germinal center B cell number	J:322180
	decreased IgG2c level	J:322180
	decreased memory B cell number	J:322180
	impaired macrophage phagocytosis	J:322180
	increased susceptibility to induced morbidity/mortality	J:322180
	increased tumor growth/size	J:322180

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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