Mcu Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mcu
mitochondrial calcium uniporter
MGI:3026965

25 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mcu^{Gt(IST11669F8)Tigm}/Mcu^{Gt(IST11669F8)Tigm} involves: C57BL/6 * C57BL/6N * CD-1	abnormal mitochondrial physiology	J:208297
	normal cardiovascular system phenotype	J:208297
	normal cellular phenotype	J:208297
	decreased body size	J:208297
	decreased body weight	J:208297
	decreased grip strength	J:208297
	normal homeostasis/metabolism phenotype	J:208297
	impaired exercise endurance	J:208297
	increased circulating lactate level	J:208297
Mcu^tm1.1Jmol/Mcu^tm1.1Jmol A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S4/SvJaeSor 129S6/SvEvTac * C57BL/6J * FVB/N	abnormal myocardial fiber morphology	J:224853
	abnormal myocardial fiber physiology	J:224853
	normal cardiovascular system phenotype	J:224853
	decreased aerobic running capacity	J:224853
	decreased cardiomyocyte apoptosis	J:224853
	decreased heart ventricle muscle contractility	J:224853
	decreased myocardial infarct size	J:224853
Mcu^tm1.1Jmol/Mcu^tm1.1Jmol Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 involves: 129S6/SvEvTac * C57BL/6 * DBA	normal cellular phenotype	J:298361
	normal liver/biliary system phenotype	J:298361
Mcu^tm1.1Jmol/Mcu^tm1.1Jmol Tg(Cdh5-cre)7Mlia/0 involves: 129S6/SvEvTac * C57BL/6J * FVB/N	abnormal mitochondrial physiology	J:235756
	decreased lung endothelial cell migration	J:235756
	decreased lung endothelial cell proliferation	J:235756
Mcu^{tm1b(EUCOMM)Hmgu}/Mcu⁺ C57BL/6N-Mcu^{tm1b(EUCOMM)Hmgu}/H	decreased bone mineral content	J:211773
	decreased lean body mass	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased fasting circulating glucose level	J:211773
	increased total body fat amount	J:211773
Mcu^{tm1b(EUCOMM)Hmgu}/Mcu^{tm1b(EUCOMM)Hmgu} C57BL/6N-Mcu^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, complete penetrance	J:211773
Mcu^{tm1c(EUCOMM)Hmgu}/Mcu^{tm1c(EUCOMM)Hmgu} Tg(Gabra6-cre)B1Lfr/0 involves: C57BL/6N * DBA/2	normal cellular phenotype	J:281635
Mcu^{tm1c(EUCOMM)Hmgu}/Mcu^{tm1c(EUCOMM)Hmgu} Tg(Pcp2-cre)2Mpin/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	abnormal mitochondrial physiology	J:281635

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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