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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrrc4b
leucine rich repeat containing 4B
MGI:3027390
34 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lrrc4bem1(IMPC)J/Lrrc4bem1(IMPC)J
C57BL/6NJ-Lrrc4bem1(IMPC)J/Mmjax 		abnormal bone structure J:211773
decreased grip strength J:211773
decreased locomotor activity J:211773
increased anxiety-related response J:211773
increased hematocrit J:211773
increased vertical activity J:211773
preweaning lethality, incomplete penetrance J:211773
Lrrc4btm1Lex/Lrrc4b+
B6.129S-Lrrc4btm1Lex 		decreased anxiety-related response J:276446
decreased locomotor activity J:276446
Lrrc4btm1Lex/Lrrc4btm1Lex
B6.129S-Lrrc4btm1Lex 		abnormal brain morphology J:276446
abnormal eating behavior J:276446
normal behavior/neurological phenotype J:276446
decreased anxiety-related response J:276446
decreased body weight J:276446
enlarged lateral ventricles J:276446
enlarged third ventricle J:276446
impaired spatial learning J:276446
increased locomotor activity J:276446
increased vertical activity J:276446
lethality, incomplete penetrance J:276446
normal nervous system phenotype J:276446
postnatal growth retardation J:276446
postnatal lethality, incomplete penetrance J:276446
preweaning lethality, incomplete penetrance J:276446
reduced long-term potentiation J:276446
Lrrc4btm1Lex/Lrrc4btm1Lex
involves: 129S/SvEv * C57BL/6J 		abnormal brain wave pattern J:276446
abnormal excitatory postsynaptic currents J:276446
normal behavior/neurological phenotype J:276446
decreased anxiety-related response J:276446
decreased body weight J:276446
decreased brain size J:276446
decreased excitatory postsynaptic current amplitude J:276446
decreased excitatory postsynaptic current frequency J:276446
decreased thigmotaxis J:276446
normal growth/size/body region phenotype J:276446
hyperactivity J:276446
impaired coordination J:276446
impaired spatial learning J:276446
increased excitatory postsynaptic current amplitude J:276446
increased susceptibility to pharmacologically induced seizures J:276446
increased vertical activity J:276446
normal mortality/aging J:276446
normal nervous system phenotype J:276446
reduced long-term potentiation J:276446
small thalamus J:276446
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory