Hdac4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hdac4
histone deacetylase 4
MGI:3036234

42 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hdac4^{em1(IMPC)Ccpcz}/Hdac4⁺ C57BL/6N-Hdac4^{em1(IMPC)Ccpcz}/Ccpcz	increased circulating alkaline phosphatase level	J:211773
	increased NK cell number	J:211773
Hdac4^{em1(IMPC)Ccpcz}/Hdac4^{em1(IMPC)Ccpcz} C57BL/6N-Hdac4^{em1(IMPC)Ccpcz}/Ccpcz	no spontaneous movement	J:211773
Hdac4^em1Hcu/Hdac4⁺ involves: C57BL/6 * CBA	abnormal food preference	J:280111
	abnormal operant conditioning behavior	J:280111
	increased anxiety-related response	J:280111
	increased coping response	J:280111
	increased food intake	J:280111
	increased grooming behavior	J:280111
	increased susceptibility to weight gain	J:280111
Hdac4^em1Hcu/Hdac4^em1Hcu involves: 129 * C57BL/6 * CBA	abnormal eating behavior	J:289570
	abnormal operant conditioning behavior	J:289570
	decreased aggression towards mice	J:289570
	decreased food intake	J:289570
	decreased locomotor activity	J:289570
	decreased susceptibility to weight gain	J:289570
	decreased vertical activity	J:289570
	increased anxiety-related response	J:289570
	increased grooming behavior	J:289570
Hdac4^{Gt(OST361114)Lex}/Hdac4^{Gt(OST361114)Lex} involves: 129S5/SvEvBrd * C57BL/6J	abnormal involuntary movement	J:152466
	abnormal spike wave discharge	J:152466
	convulsive seizures	J:152466
	decreased body weight	J:152466
	environmentally induced seizures	J:152466
	increased blinking frequency	J:152466
	increased locomotor activity	J:152466
	increased thermal nociceptive threshold	J:152466
	normal nervous system phenotype	J:152466
	normal skeleton phenotype	J:152466
	tonic seizures	J:152466
Hdac4^tm1Eno/Hdac4^tm1Eno either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6)	abnormal bone ossification	J:94631
	abnormal costal cartilage morphology	J:94631
	abnormal long bone hypertrophic chondrocyte zone	J:94631
	abnormal vertebrae morphology	J:94631
	decreased body size	J:94631
	domed cranium	J:94631
	exencephaly	J:94631
	postnatal lethality, complete penetrance	J:94631
	premature endochondral bone ossification	J:94631
	premature lambdoid suture closure	J:94631
Hdac4^tm1Eno/Hdac4^tm1Eno involves: 129	normal muscle phenotype	J:127416
Hdac4^tm2.1Eno/Hdac4^tm2.1Eno involves: 129S/SvEv	normal muscle phenotype	J:127416
Hdac4^tm2.1Eno/Hdac4^tm2.1Eno Tg(Myog-cre)1Eno/0 involves: 129S/SvEv	abnormal motor nerve collateral sprouting	J:155806
Tg(Col2a1-Hdac4)1Eno/0 Not Specified	abnormal long bone hypertrophic chondrocyte zone	J:94631
	abnormal trabecular bone morphology	J:94631
	decreased length of long bones	J:94631
	decreased osteoblast cell number	J:94631

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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