Nlrc4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nlrc4
NLR family, CARD domain containing 4
MGI:3036243

27 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nlrc4^em1Vnce/Nlrc4^em1Vnce C57BL/6-Nlrc4^em1Vnce	decreased inflammatory response	J:294930
	decreased lactate dehydrogenase level	J:294930
	increased susceptibility to bacterial infection induced morbidity/mortality	J:294930
	normal mortality/aging	J:294930
	normal reproductive system phenotype	J:294930
Nlrc4^em2Vnce/Nlrc4^em2Vnce C57BL/6-Nlrc4^em2Vnce	decreased inflammatory response	J:294930
	decreased lactate dehydrogenase level	J:294930
	normal mortality/aging	J:294930
	normal reproductive system phenotype	J:294930
Nlrc4^em3Vnce/Nlrc4^em3Vnce C57BL/6-Nlrc4^em3Vnce	normal homeostasis/metabolism phenotype	J:294930
	normal immune system phenotype	J:294930
	normal mortality/aging	J:294930
	normal reproductive system phenotype	J:294930
Nlrc4^m1Btlr/Nlrc4⁺ C57BL/6J-Nlrc4^m1Btlr	decreased interleukin-1 beta secretion	J:225933
Nlrc4^m1Btlr/Nlrc4^m1Btlr C57BL/6J-Nlrc4^m1Btlr	decreased interleukin-1 beta secretion	J:225933
Nlrc4^tm1Gln/Nlrc4^tm1Gln involves: 129S5/SvEvBrd	normal immune system phenotype	J:173245
Nlrc4^tm1Gne/Nlrc4^tm1Gne involves: C57BL/6N	normal immune system phenotype	J:189256
Nlrc4^tm1Nnz/Nlrc4^tm1Nnz involves: 129 * C57BL/6J	abnormal macrophage physiology	J:112671, J:117251
Nlrc4^tm1Nnz/Nlrc4^tm1Nnz involves: 129 * C57BL/6J	increased susceptibility to bacterial infection	J:117251
Nlrc4^tm1Vmd/Nlrc4^tm1Vmd C57BL/6N-Nlrc4^tm1Vmd	abnormal cell death	J:91292
Nlrc4^tm1Vmd/Nlrc4^tm1Vmd C57BL/6N-Nlrc4^tm1Vmd	decreased interleukin-1 beta secretion	J:91292
Nlrc4^tm1Vmd/Nlrc4^tm1Vmd involves: C57BL/6N	abnormal cytokine secretion	J:106976
Nlrc4^tm1Vmd/Nlrc4^tm1Vmd involves: C57BL/6N	abnormal response to infection	J:106976
Tg(Cd74-Nlrc4*)1Kyas/0 involves: C57BL/6N	abnormal spleen morphology	J:219652
	autoimmune arthritis	J:219652
	dermatitis	J:219652
	enlarged spleen	J:219652
	increased circulating interleukin-1 beta level	J:219652
	increased circulating interleukin-17 level	J:219652
	increased inflammatory response	J:219652
	increased interleukin-1 beta secretion	J:219652
	increased neutrophil cell number	J:219652
	increased splenocyte number	J:219652
	increased T cell number	J:219652
	joint inflammation	J:219652
	joint swelling	J:219652
	skin inflammation	J:219652

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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