Vtcn1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Vtcn1
V-set domain containing T cell activation inhibitor 1
MGI:3039619

16 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Vtcn1^tm1Lpc/Vtcn1^tm1Lpc B6.129S-Vtcn1^tm1Lpc	abnormal myelopoiesis	J:145712
	decreased susceptibility to bacterial infection	J:145712
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:145712
	increased neutrophil cell number	J:145712
Vtcn1^tm1Mak/Vtcn1^tm1Mak C.Cg-Vtcn1^tm1Mak	decreased interleukin-4 secretion	J:112130
	decreased susceptibility to parasitic infection	J:112130
	increased interferon-gamma secretion	J:112130
Vtcn1^tm1Mak/Vtcn1^tm1Mak involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:112130
Vtcn1^tm1Xxz/Vtcn1^tm1Xxz involves: 129S4/SvJae * BALB/c * C57BL/6	increased CD4-positive, alpha-beta T cell number	J:177612
	increased circulating glucose level	J:177612
	increased interleukin-17 secretion	J:177612
	increased susceptibility to autoimmune diabetes	J:177612
	increased susceptibility to experimental autoimmune encephalomyelitis	J:177612
	increased susceptibility to induced morbidity/mortality	J:177612
	increased T-helper 1 cell number	J:177612
	increased T-helper 17 cell number	J:177612

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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