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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
MGI:3039785
43 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Syngap1tm1.1Mabk/Syngap1tm1.1Mabk
involves: 129S1/Sv * C57BL/6
abnormal hippocampus pyramidal cell morphology J:93969
abnormal motor capabilities/coordination/movement J:93969
increased miniature excitatory postsynaptic current amplitude J:93969
increased miniature excitatory postsynaptic current frequency J:93969
increased neuron apoptosis J:101084
postnatal growth retardation J:93969
postnatal lethality, complete penetrance J:93969
tremors J:93969
weakness J:93969
Syngap1tm1.1Mabk/Syngap1tm1.2Mabk
Tg(Camk2a-cre)2834Lusc/0
involves: 129S1/Sv * C57BL/6
increased neuron apoptosis J:101084
postnatal lethality, incomplete penetrance J:101084
Syngap1tm1Grnt/Syngap1+
involves: 129P2/OlaHsd * MF1
abnormal spatial learning J:98903
impaired synaptic plasticity J:98903
reduced long-term potentiation J:98903
Syngap1tm1Grnt/Syngap1tm1Grnt
involves: 129P2/OlaHsd * MF1
decreased body size J:97490
postnatal lethality, complete penetrance J:97490, J:98903
Syngap1tm1Rlh/Syngap1+
involves: 129S1/Sv * 129X1/SvJ
abnormal CNS synaptic transmission J:193208
abnormal dendrite morphology J:193208
abnormal dendritic spine morphology J:193208
abnormal discrimination learning J:193208
abnormal excitatory postsynaptic potential J:193208
abnormal glutamate-mediated receptor currents J:193208
abnormal miniature excitatory postsynaptic currents J:193208
abnormal miniature inhibitory postsynaptic currents J:193208
audiogenic seizures J:193208
normal behavior/neurological phenotype J:193208
enhanced AMPA-mediated synaptic currents J:193208
hyperactivity J:193208
increased miniature inhibitory postsynaptic current amplitude J:193208
increased miniature inhibitory postsynaptic current frequency J:193208
increased susceptibility to pharmacologically induced seizures J:193208
normal nervous system phenotype J:193208
Syngap1tm1Rlh/Syngap1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
reduced long-term potentiation J:97391
Syngap1tm1Rlh/Syngap1+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal social/conspecific interaction behavior J:194146
abnormal spatial working memory J:194146
decreased anxiety-related response J:194146
decreased prepulse inhibition J:194146
impaired cued conditioning behavior J:194146
increased horizontal stereotypic behavior J:194146
increased locomotor activity J:194146
increased startle reflex J:194146
social withdrawal J:194146
Syngap1tm1Rlh/Syngap1tm1Rlh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal neuron morphology J:97391
abnormal suckling behavior J:97391
bradykinesia J:97391
decreased body size J:97391
decreased brain size J:97391
postnatal lethality, complete penetrance J:97391
Syngap1tm1Rlh/Syngap1tm1Rlh
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
postnatal lethality, complete penetrance J:194146

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory