Fan1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fan1
FANCD2/FANCI-associated nuclease 1
MGI:3045266

22 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fan1^em1Mem/Fan1^em1Mem C57BL/6J-Fan1^em1Mem	abnormal cell nucleus morphology	J:298297
Fan1^em1Mem/Fan1^em1Mem C57BL/6J-Fan1^em1Mem	increased cellular sensitivity to alkylating agents	J:298297
Fan1^em2Mem/Fan1^em2Mem C57BL/6J-Fan1^em2Mem	abnormal cell nucleus morphology	J:298297
Fan1^em2Mem/Fan1^em2Mem C57BL/6J-Fan1^em2Mem	increased cellular sensitivity to alkylating agents	J:298297
Fan1^tm1.1Jrou/Fan1^tm1.1Jrou involves: 129P2/OlaHsd	abnormal DNA repair	J:232403
	abnormal renal tubule epithelium morphology	J:232403
	abnormal renal tubule morphology	J:232403
	dilated renal tubule	J:232403
	increased physiological sensitivity to xenobiotic	J:232403
	polyploidy	J:232403
	renal tubule atrophy	J:232403
	normal renal/urinary system phenotype	J:232403
Fan1^{tm1a(KOMP)Wtsi}/Fan1^{tm1a(KOMP)Wtsi} 129S1.B6-Fan1^{tm1a(KOMP)Wtsi}	cachexia	J:242198
	dehydration	J:242198
	increased blood urea nitrogen level	J:242198
	increased kidney cell proliferation	J:242198
	increased physiological sensitivity to xenobiotic	J:242198
	increased sensitivity to induced cell death	J:242198
	increased susceptibility to xenobiotic induced morbidity/mortality	J:242198
	renal interstitial fibrosis	J:242198
	normal renal/urinary system phenotype	J:242198
	tubulointerstitial nephritis	J:242198
Fan1^{tm1d(KOMP)Wtsi}/Fan1^{tm1d(KOMP)Wtsi} involves: C57BL/6N * FVB/N	abnormal cell nucleus morphology	J:232402
	abnormal hematopoietic stem cell physiology	J:232402
	abnormal renal tubule morphology	J:232402
	decreased liver function	J:232402
	normal hematopoietic system phenotype	J:232402
	increased hepatocyte karyomegaly	J:232402
	increased physiological sensitivity to xenobiotic	J:232402
	increased susceptibility to xenobiotic induced morbidity/mortality	J:232402
	polyploidy	J:232402
	normal renal/urinary system phenotype	J:232402

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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