Unc13a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Unc13a
unc-13 homolog A
MGI:3051532

19 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Unc13a^tm1Bros/Unc13a⁺ involves: 129	abnormal pancreatic islet morphology	J:108689
	decreased insulin secretion	J:108689, J:215257
	impaired glucose tolerance	J:108689
Unc13a^tm1Bros/Unc13a^tm1Bros involves: 129	abnormal CNS synaptic transmission	J:138035
	abnormal synaptic vesicle number	J:56513, J:77339
	absent gastric milk in neonates	J:138035
	decreased neurotransmitter release	J:77339
	decreased pulmonary respiratory rate	J:56513
	neonatal lethality, complete penetrance	J:56513
	normal nervous system phenotype	J:56513
	postnatal lethality, complete penetrance	J:138035
	weakness	J:56513
Unc13a^tm2Bros/Unc13a⁺ Not Specified	abnormal pancreatic islet morphology	J:108689
Unc13a^tm2Bros/Unc13a⁺ Not Specified	normal homeostasis/metabolism phenotype	J:108689
Unc13a^tm2Bros/Unc13a^tm2Bros involves: FVB/N	abnormal excitatory postsynaptic currents	J:74347
	abnormal synaptic vesicle morphology	J:74347
	abnormal synaptic vesicle number	J:74347
	abnormal synaptic vesicle recycling	J:74347
	neonatal lethality, complete penetrance	J:74347
Unc13a^tm2Bros/Unc13a^tm2Bros Not Specified	neonatal lethality, complete penetrance	J:117827
Unc13a^tm3Bros/Unc13a^tm3Bros involves: 129 * C57BL/6	normal nervous system phenotype	J:116766
Unc13a^tm3Bros/Unc13a^tm3Bros involves: 129 * C57BL/6	normal reproductive system phenotype	J:116766
Unc13a^tm4.1Bros/Unc13a^tm4.1Bros involves: FVB/N	abnormal CNS synaptic transmission	J:201701
	abnormal neuron physiology	J:201701
	decreased synaptic depression	J:201701

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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