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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mdc1
mediator of DNA damage checkpoint 1
MGI:3525201
17 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mdc1em1(IMPC)Bay/Mdc1em1(IMPC)Bay
C57BL/6N-Mdc1em1(IMPC)Bay/BayMmucd 		decreased cardiac output J:211773
decreased cardiac stroke volume J:211773
decreased locomotor activity J:211773
male infertility J:211773
Mdc1Gt(OST441263)Lex/Mdc1Gt(OST441263)Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal class switch recombination J:137341
abnormal double-strand DNA break repair J:137341
decreased cell proliferation J:137341
decreased litter size J:137341
increased cellular sensitivity to ionizing radiation J:137341
increased mortality induced by ionizing radiation J:137341
male infertility J:137341
oligozoospermia J:137341
postnatal growth retardation J:137341
small seminiferous tubules J:137341
small spleen J:137341
small testis J:137341
small thymus J:137341
spontaneous chromosome breakage J:137341
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory