Lin28b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lin28b
lin-28 homolog B
MGI:3584032

47 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm2(CAG-Lin28b,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Tg(Dbh-icre)1Gsc/0 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	increased neuroblastoma incidence	J:241988
Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	decreased body size	J:199720
Lin28b^tm1.2Gqda/Lin28b^tm1.2Gqda STOCK Lin28b^tm1.2Gqda/J	no abnormal phenotype detected	J:101977
Lin28b^{tm1b(EUCOMM)Hmgu}/Lin28b^{tm1b(EUCOMM)Hmgu} C57BL/6N-Lin28b^{tm1b(EUCOMM)Hmgu}/J	decreased exploration in new environment	J:211773
Lin28b^tm1Gqda/Lin28b^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvEv * 129S4/SvJae * C57BL/6	decreased body size	J:199720
	normal growth/size/body region phenotype	J:199720
Lin28b^tm1Gqda/Lin28b^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	decreased body size	J:199720
	impaired glucose tolerance	J:199720
	insulin resistance	J:199720
	normal muscle phenotype	J:199720
Tg(Vav1-Lin28b)C3Apla/0 involves: C57BL/6	abnormal cytokine level	J:189197
	abnormal inflammatory response	J:189197
	abnormal T cell differentiation	J:189197
	abnormal thymus cell ratio	J:189197
	abnormal thymus cortex morphology	J:189197
	abnormal thymus corticomedullary boundary morphology	J:189197
	anemia	J:189197
	ascites	J:189197
	decreased CD4-positive, alpha-beta T cell number	J:189197
	decreased CD8-positive, alpha-beta T cell number	J:189197
	decreased double-positive T cell number	J:189197
	decreased leukocyte cell number	J:189197
	decreased lymphocyte cell number	J:189197
	decreased thymocyte number	J:189197
	enlarged lymph nodes	J:189197
	enlarged spleen	J:189197
	enlarged thymus medulla	J:189197
	hunched posture	J:189197
	increased CD8-positive, alpha-beta T cell number	J:189197
	increased effector memory CD4-positive, alpha-beta T cell number	J:189197
	increased effector memory CD8-positive, alpha-beta T cell number	J:189197
	increased eosinophil cell number	J:189197
	increased IgG level	J:189197
	increased neutrophil cell number	J:189197
	increased T cell derived lymphoma incidence	J:189197
	increased T cell proliferation	J:189197
	lethargy	J:189197
	pleural effusion	J:189197
	premature death	J:189197
	ruffled hair	J:189197
Tg(Vil1-Lin28b,-tdTomato)HiAru/0 involves: C57BL/6J * SJL	abnormal intestinal goblet cell morphology	J:202923
	abnormal jejunum crypts of Lieberkuhn morphology	J:202923
	decreased Paneth cell number	J:202923
	increased intestinal adenoma incidence	J:202923
	increased small intestine adenocarcinoma incidence	J:202923
Tg(Vil1-Lin28b,-tdTomato)LoAru/0 involves: C57BL/6J * SJL	abnormal intestinal mucosa morphology	J:202923
	abnormal small intestine morphology	J:202923
	decreased Paneth cell number	J:202923
	normal digestive/alimentary phenotype	J:202923
Tg(Vil1-Lin28b,-tdTomato)MedAru/0 involves: C57BL/6J * SJL	abnormal intestinal mucosa morphology	J:202923
	abnormal small intestine crypts of Lieberkuhn morphology	J:202923
	abnormal small intestine morphology	J:202923
	decreased Paneth cell number	J:202923
	increased intestinal adenoma incidence	J:202923
	increased small intestine adenocarcinoma incidence	J:202923

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24