Lin28b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lin28b
lin-28 homolog B
MGI:3584032

47 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm2(CAG-Lin28b,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Tg(Dbh-icre)1Gsc/0 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	increased neuroblastoma incidence	J:241988
Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	decreased body size	J:199720
Lin28b^tm1.2Gqda/Lin28b^tm1.2Gqda STOCK Lin28b^tm1.2Gqda/J	no abnormal phenotype detected	J:101977
Lin28b^{tm1b(EUCOMM)Hmgu}/Lin28b^{tm1b(EUCOMM)Hmgu} C57BL/6N-Lin28b^{tm1b(EUCOMM)Hmgu}/J	decreased exploration in new environment	J:211773
Lin28b^tm1Gqda/Lin28b^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvEv * 129S4/SvJae * C57BL/6	decreased body size	J:199720
	normal growth/size/body region phenotype	J:199720
Lin28b^tm1Gqda/Lin28b^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	decreased body size	J:199720
	impaired glucose tolerance	J:199720
	insulin resistance	J:199720
	normal muscle phenotype	J:199720
Tg(Vav1-Lin28b)C3Apla/0 involves: C57BL/6	abnormal cytokine level	J:189197
	abnormal inflammatory response	J:189197
	abnormal T cell differentiation	J:189197
	abnormal thymus cell ratio	J:189197
	abnormal thymus cortex morphology	J:189197
	abnormal thymus corticomedullary boundary morphology	J:189197
	anemia	J:189197
	ascites	J:189197
	decreased CD4-positive, alpha-beta T cell number	J:189197
	decreased CD8-positive, alpha-beta T cell number	J:189197
	decreased double-positive T cell number	J:189197
	decreased leukocyte cell number	J:189197
	decreased lymphocyte cell number	J:189197
	decreased thymocyte number	J:189197
	enlarged lymph nodes	J:189197
	enlarged spleen	J:189197
	enlarged thymus medulla	J:189197
	hunched posture	J:189197
	increased CD8-positive, alpha-beta T cell number	J:189197
	increased effector memory CD4-positive, alpha-beta T cell number	J:189197
	increased effector memory CD8-positive, alpha-beta T cell number	J:189197
	increased eosinophil cell number	J:189197
	increased IgG level	J:189197
	increased neutrophil cell number	J:189197
	increased T cell derived lymphoma incidence	J:189197
	increased T cell proliferation	J:189197
	lethargy	J:189197
	pleural effusion	J:189197
	premature death	J:189197
	ruffled hair	J:189197
Tg(Vil1-Lin28b,-tdTomato)HiAru/0 involves: C57BL/6J * SJL	abnormal intestinal goblet cell morphology	J:202923
	abnormal jejunum crypts of Lieberkuhn morphology	J:202923
	decreased Paneth cell number	J:202923
	increased intestinal adenoma incidence	J:202923
	increased small intestine adenocarcinoma incidence	J:202923
Tg(Vil1-Lin28b,-tdTomato)LoAru/0 involves: C57BL/6J * SJL	abnormal intestinal mucosa morphology	J:202923
	abnormal small intestine morphology	J:202923
	decreased Paneth cell number	J:202923
	normal digestive/alimentary phenotype	J:202923
Tg(Vil1-Lin28b,-tdTomato)MedAru/0 involves: C57BL/6J * SJL	abnormal intestinal mucosa morphology	J:202923
	abnormal small intestine crypts of Lieberkuhn morphology	J:202923
	abnormal small intestine morphology	J:202923
	decreased Paneth cell number	J:202923
	increased intestinal adenoma incidence	J:202923
	increased small intestine adenocarcinoma incidence	J:202923

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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