Firrm Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Firrm
FIGNL1 interacting regulator of recombination and mitosis
MGI:3590554

32 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Firrm^em1.1Gpt/Firrm^em1.1Gpt involves: C57BL/6JGpt	embryonic growth arrest	J:344887
Firrm^em1.1Gpt/Firrm^em1.1Gpt involves: C57BL/6JGpt	embryonic lethality, complete penetrance	J:344887
Firrm^em1Gpt/Firrm^em1Gpt Stra8^{em1(GFP/cre)Smoc}/Stra8⁺ involves: C57BL/6JGpt	abnormal chromosomal synapsis	J:344887
	abnormal female meiosis	J:344887
	abnormal male meiosis	J:344887
	abnormal seminiferous tubule morphology	J:344887
	abnormal synaptonemal complex	J:344887
	absent oocytes	J:344887
	arrest of male meiosis	J:344887
	arrest of spermatogenesis	J:344887
	azoospermia	J:344887
	decreased male germ cell number	J:344887
	decreased oocyte number	J:344887
	decreased testis weight	J:344887
	female infertility	J:344887
	increased male germ cell apoptosis	J:344887
	infertility	J:344887
	male infertility	J:344887
	ovary degeneration	J:344887
	premature ovarian failure	J:344887
	small ovary	J:344887
	small seminiferous tubules	J:344887
	small testis	J:344887
Firrm^{tm1a(EUCOMM)Hmgu}/Firrm⁺ C57BL/6N-Firrm^{tm1a(EUCOMM)Hmgu}/H	abnormal bone mineralization	J:165965
	decreased bone mineral density	J:165965
	increased circulating alkaline phosphatase level	J:165965
	increased circulating cholesterol level	J:165965
	increased circulating HDL cholesterol level	J:165965
	increased mean corpuscular volume	J:165965
Firrm^{tm1b(EUCOMM)Hmgu}/Firrm⁺ C57BL/6N-Firrm^{tm1b(EUCOMM)Hmgu}/H	abnormal pelvic girdle bone morphology	J:211773
	increased circulating amylase level	J:211773
Firrm^{tm1b(EUCOMM)Hmgu}/Firrm^{tm1b(EUCOMM)Hmgu} C57BL/6N-Firrm^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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