Piezo1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Piezo1
piezo-type mechanosensitive ion channel component 1
MGI:3603204

38 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Piezo1^{Gt(RST343)Byg}/Piezo1⁺ involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:212179
Piezo1^{Gt(RST343)Byg}/Piezo1^{Gt(RST343)Byg} involves: 129P2/OlaHsd * C57BL/6J	abnormal developmental vascular remodeling	J:212179
	abnormal intersomitic vessel morphology	J:212179
	abnormal vitelline vascular remodeling	J:212179
	absent organized vascular network	J:212179
	normal cardiovascular system phenotype	J:212179
	disorganized yolk sac vascular plexus	J:212179
	embryonic growth retardation	J:212179
	embryonic lethality during organogenesis, incomplete penetrance	J:212179
	lethality throughout fetal growth and development, complete penetrance	J:212179
	pericardial effusion	J:212179
Piezo1^{tm1a(KOMP)Wtsi}/Piezo1⁺ involves: C57BL/6J * C57BL/6N	abnormal vascular endothelial cell morphology	J:217082
Piezo1^{tm1a(KOMP)Wtsi}/Piezo1^{tm1a(KOMP)Wtsi} involves: C57BL/6J * C57BL/6N	abnormal enzyme/coenzyme activity	J:217082
	abnormal vascular endothelial cell morphology	J:217082
	abnormal vascular endothelial cell physiology	J:217082
	abnormal vitelline vasculature morphology	J:217082
	disorganized yolk sac vascular plexus	J:217082
	embryonic growth retardation	J:217082
	embryonic lethality during organogenesis, incomplete penetrance	J:217082
	lethality throughout fetal growth and development, complete penetrance	J:217082
Piezo1^{tm1b(KOMP)Wtsi}/Piezo1⁺ C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/MbpMmucd	abnormal embryo size	J:211773
	abnormal placenta size	J:211773
Piezo1^{tm1b(KOMP)Wtsi}/Piezo1⁺ C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/Ucd	abnormal urinary bladder morphology	J:211773
	decreased locomotor activity	J:211773
	increased circulating alanine transaminase level	J:211773
Piezo1^{tm1b(KOMP)Wtsi}/Piezo1^{tm1b(KOMP)Wtsi} C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/MbpMmucd	abnormal embryo size	J:211773
	abnormal limb bud morphology	J:211773
	abnormal placenta size	J:211773
	embryonic growth retardation	J:211773
	pale yolk sac	J:211773
	pallor	J:211773
Piezo1^{tm1b(KOMP)Wtsi}/Piezo1^{tm1b(KOMP)Wtsi} C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/Ucd	preweaning lethality, complete penetrance	J:211773
Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi} Tg(Tek-cre)12Flv/0 involves: C57BL/6J * C57BL/6N	abnormal vitelline vasculature morphology	J:217082
	embryonic growth retardation	J:217082
Piezo1^tm2.1Apat/Piezo1^tm2.1Apat Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: C57BL/6 * C57BL/10 * CBA	abnormal calcium ion homeostasis	J:229436
	abnormal erythrocyte ion transport	J:229436
	abnormal spleen morphology	J:229436
	abnormal splenic cell ratio	J:229436
	decreased blood osmolality	J:229436
	decreased circulating haptoglobin level	J:229436
	decreased erythrocyte cell number	J:229436
	decreased hematocrit	J:229436
	decreased mean corpuscular hemoglobin concentration	J:229436
	increased erythrocyte osmotic fragility	J:229436
	increased mean corpuscular hemoglobin	J:229436
	increased mean corpuscular volume	J:229436
	increased red blood cell distribution width	J:229436
	macrocytosis	J:229436

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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