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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mirc14
microRNA cluster 14, including Mir181a-1 through Mir181b-1
MGI:5313566
24 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mirc14tm1.1Ankr/Mirc14tm1.1Ankr
involves: C57BL/6 		abnormal alpha-beta intraepithelial T cell morphology J:196134
abnormal NK T cell morphology J:196134
abnormal T cell differentiation J:196134
decreased double-positive T cell number J:196134
decreased interferon-gamma secretion J:196134
decreased interleukin-4 secretion J:196134
decreased interleukin-13 secretion J:196134
decreased NK T cell number J:196134
normal immune system phenotype J:196134
increased CD4-positive, alpha-beta T cell number J:196134
Mirc14tm1.1Czc/Mirc14tm1.1Czc
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6) 		decreased double-positive T cell number J:188125
thymus hypoplasia J:188125
Mirc14tm1.1Flv/Mirc14tm1.1Flv
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * C57BL/6N * DBA/2 * SJL 		decreased NK T cell number J:203157
Mirc14tm1.2Czc/Mirc14tm1.2Czc
either: (involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6) 		decreased B cell number J:188125
decreased DN3 thymocyte number J:188125
decreased double-positive T cell number J:188125
decreased germinal center B cell number J:188125
decreased thymocyte number J:188125
increased CD4-positive, alpha-beta T cell number J:188125
increased marginal zone B cell number J:188125
increased tumor latency J:188125
Mirc14tm1.2Flv/Mirc14tm1.2Flv
involves: C57BL/6 * C57BL/6N * FVB/N * SJL 		abnormal T cell differentiation J:203157
abnormal T cell physiology J:203157
abnormal T cell receptor V(D)J recombination J:203157
decreased B cell number J:203157
decreased CD4-positive, alpha-beta T cell number J:203157
decreased CD8-positive, alpha-beta T cell number J:203157
decreased DN1 thymic pro-T cell number J:203157
decreased double-positive T cell number J:203157
decreased NK T cell number J:203157
decreased T cell proliferation J:203157
decreased thymocyte apoptosis J:203157
decreased thymocyte number J:203157
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory