Igs1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Igs1
intergenic site 1
MGI:5319510

29 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ednrb^tm1.1Nat/Ednrb^tm1.2Nat Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Pax6-cre,GFP)2Pgr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal retina vasculature morphology	J:201133
Fzd4^tm1Nat/Fzd4⁺ Igs1^{tm2(CAG-Bgeo,-Ndp,-EGFP)Nat}/Igs1^{tm2(CAG-Bgeo,-Ndp,-EGFP)Nat} Edil3^{Tg(Sox2-cre)1Amc}/? involves: 129 * C57BL/6 * CBA	abnormal angiogenesis	J:154020
	abnormal descending aorta morphology	J:154020
	embryonic growth retardation	J:154020
	embryonic lethality, incomplete penetrance	J:154020
Fzd4^tm1Nat/Fzd4^tm1Nat Igs1^{tm2(CAG-Bgeo,-Ndp,-EGFP)Nat}/Igs1^{tm2(CAG-Bgeo,-Ndp,-EGFP)Nat} Edil3^{Tg(Sox2-cre)1Amc}/? involves: 129 * C57BL/6 * CBA	normal cardiovascular system phenotype	J:154020
	normal growth/size/body region phenotype	J:154020
	normal mortality/aging	J:154020
Igs1^{tm4(CAG-Bgeo,-Vangl2)Nat}/Igs1^{tm4(CAG-Bgeo,-Vangl2)Nat} involves: 129 * C57BL/6	abnormal metabolism	J:101977
Igs1^{tm6(CAG-Bgeo,-Wnt5a)Nat}/Igs1⁺ involves: 129 * C57BL/6	no abnormal phenotype detected	J:101977
Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	cleft palate	J:201133
	failure of eyelid fusion	J:201133
	postnatal lethality	J:201133
Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal vascular development	J:201133
	embryonic growth retardation	J:201133
	enlarged heart	J:201133
	internal hemorrhage	J:201133
	open neural tube	J:201133
	prenatal lethality	J:201133
Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(KRT5-cre)5132Jlj/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J	abnormal dermal pigmentation	J:201133
Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Pax6-cre,GFP)2Pgr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal retina morphology	J:201133
	abnormal retina vasculature morphology	J:201133
	hypoxia	J:201133
	thin retina ganglion layer	J:201133
	thin retina inner nuclear layer	J:201133
	thin retina outer nuclear layer	J:201133
Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Six3-cre)69Frty/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal angiogenesis	J:201133
	abnormal retina blood vessel morphology	J:201133
	abnormal retina blood vessel pattern	J:201133
	abnormal retina morphology	J:201133
	abnormal retina vasculature morphology	J:201133
	hypoxia	J:201133
	retina detachment	J:201133
	retina fibrosis	J:201133
	retina fold	J:201133
	thin retina ganglion layer	J:201133
	thin retina inner nuclear layer	J:201133
	thin retina outer nuclear layer	J:201133
Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Pdgfra-cre)1Clc/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal retina vasculature morphology	J:201133
Lrp5^tm1Kry/Lrp5^tm1Kry Igs1^{tm2(CAG-Bgeo,-Ndp,-EGFP)Nat}/Igs1^{tm2(CAG-Bgeo,-Ndp,-EGFP)Nat} Edil3^{Tg(Sox2-cre)1Amc}/? involves: 129 * C57BL/6 * CBA	abnormal angiogenesis	J:154020
	abnormal descending aorta morphology	J:154020
	embryonic growth retardation	J:154020
	embryonic lethality, incomplete penetrance	J:154020

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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