Mirc32 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mirc32
microRNA cluster 32, including Mir143 and Mir145a
MGI:5447365

28 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mirc32^tm1.1Jtm/Mirc32^tm1.1Jtm Tg(Myh11-cre,-EGFP)2Mik/? B6.Cg-Mirc32^tm1.1Jtm Tg(Myh11-cre,-EGFP)2Mik	abnormal colon morphology	J:214382
	abnormal intestinal mucosa morphology	J:214382
	abnormal large intestine crypts of Lieberkuhn morphology	J:214382
	colonic necrosis	J:214382
	impaired intestine regeneration	J:214382
	increased susceptibility to induced colitis	J:214382
	intestinal ulcer	J:214382
Mirc32^tm1.1Jtm/Mirc32^tm1.1Jtm Twist2^tm1(cre)Dor/Twist2⁺ B6.129(Cg)-Twist2^{tm1.1(cre)Dor} Mirc32^tm1.1Jtm	abnormal colon morphology	J:214382
	abnormal intestinal mucosa morphology	J:214382
	abnormal large intestine crypts of Lieberkuhn morphology	J:214382
	abnormal susceptibility to induced morbidity/mortality	J:214382
	colonic necrosis	J:214382
	impaired intestine regeneration	J:214382
	increased susceptibility to induced colitis	J:214382
	intestinal ulcer	J:214382
Mirc32^tm1.2Eno/Mirc32^tm1.2Eno involves: 129S/SvEv * C57BL/6	abnormal blood vessel morphology	J:152458
	abnormal vascular smooth muscle morphology	J:152458
	abnormal vascular wound healing	J:152458
	circling	J:152458
	impaired coordination	J:152458
	increased susceptibility to induced morbidity/mortality	J:152458
	seizures	J:152458
	vascular smooth muscle hypotrophy	J:152458
Mirc32^tm1.2Jtm/Mirc32^tm1.2Jtm B6.129(Cg)-Mirc32^tm1.2Jtm	abnormal colon morphology	J:214382
	abnormal intestinal mucosa morphology	J:214382
	abnormal large intestine crypts of Lieberkuhn morphology	J:214382
	abnormal susceptibility to induced morbidity/mortality	J:214382
	colonic necrosis	J:214382
	impaired intestine regeneration	J:214382
	increased susceptibility to induced colitis	J:214382
	intestinal ulcer	J:214382
Mirc32^tm1Gcon/Mirc32^tm1Gcon involves: 129S1/Sv * 129X1/SvJ	abnormal aorta smooth muscle morphology	J:159593
	abnormal aorta tunica intima morphology	J:159593
	abnormal aorta tunica media morphology	J:159593
	abnormal response/metabolism to endogenous compounds	J:159593
	abnormal vascular smooth muscle physiology	J:159593
	decreased systemic arterial systolic blood pressure	J:159593
Mirc32^tm1Jtm/Mirc32^tm1Jtm involves: 129	no abnormal phenotype detected	J:214382
Mirc32^tm1Thbr/Mirc32^tm1Thbr involves: 129	improved glucose tolerance	J:176266
Mirc32^tm1Thbr/Mirc32^tm1Thbr involves: 129	increased insulin sensitivity	J:176266
Mirc32^tm1Thbr/Mirc32^tm1Thbr involves: 129/Sv * C57BL/6	abnormal artery morphology	J:152702
	abnormal vascular smooth muscle morphology	J:152702
	abnormal vascular wound healing	J:152702
	decreased systemic arterial diastolic blood pressure	J:152702
	decreased systemic arterial systolic blood pressure	J:152702
	decreased vasoconstriction	J:152702
	vascular smooth muscle hypotrophy	J:152702

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24