Sh3gl2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sh3gl2
SH3-domain GRB2-like 2
MGI:700009

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Sh3gl1^tm1Pdc/Sh3gl1^tm1Pdc Sh3gl2^tm1Pdc/Sh3gl2⁺ Sh3gl3^tm1.2Itl/Sh3gl3^tm1.2Itl involves: 129S1/Sv * C57BL/6 * C57BL/6J * FVB/N * SJL	seizures	J:178947
Sh3gl1^tm1Pdc/Sh3gl1^tm1Pdc Sh3gl2^tm1Pdc/Sh3gl2^tm1Pdc involves: 129	abnormal axon morphology	J:178947
	abnormal hippocampal mossy fiber morphology	J:178947
	decreased body weight	J:178947
	impaired coordination	J:178947
	neonatal lethality, incomplete penetrance	J:178947
	neurodegeneration	J:178947
	postnatal growth retardation	J:178947
	seizures	J:178947
Sh3gl1^tm1Pdc/Sh3gl1^tm1Pdc Sh3gl2^tm1Pdc/Sh3gl2^tm1Pdc Sh3gl3^tm1.2Itl/Sh3gl3^tm1.2Itl involves: 129S1/Sv * C57BL/6 * C57BL/6J * FVB/N * SJL	abnormal miniature excitatory postsynaptic currents	J:178947
	abnormal synapse morphology	J:178947
	abnormal synaptic vesicle number	J:178947
	abnormal synaptic vesicle recycling	J:178947
	absent gastric milk in neonates	J:178947
	decreased birth body size	J:178947
	decreased excitatory postsynaptic current amplitude	J:178947
	increased synaptic depression	J:178947
	neonatal lethality, complete penetrance	J:178947
	respiratory distress	J:178947
Sh3gl2^tm1Pdc/Sh3gl2^tm1Pdc Sh3gl3^tm1.2Itl/Sh3gl3^tm1.2Itl involves: 129S1/Sv * C57BL/6 * C57BL/6J * FVB/N * SJL	normal mortality/aging	J:178947

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24