Pzp Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pzp
PZP, alpha-2-macroglobulin like
MGI:87854

29 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pzp^tm1Lex/Pzp^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	decreased heart rate	J:103485
	decreased locomotor activity	J:103485
	increased bone mineral density	J:103485
Pzp^tm1Vln/Pzp⁺ involves: 129P2/OlaHsd * C57BL	no abnormal phenotype detected	J:28328
Pzp^tm1Vln/Pzp^tm1Vln B6.129P2-Pzp^tm1Vln	abnormal cytokine secretion	J:113532
	normal homeostasis/metabolism phenotype	J:113532
	impaired febrile response	J:113532
Pzp^tm1Vln/Pzp^tm1Vln B.129P2-Pzp^tm1Vln	abnormal cytokine level	J:57485
	abnormal enzyme/coenzyme activity	J:57485
	abnormal pancreatic acinar cell morphology	J:57485
	abnormal pancreatic acinus morphology	J:57485
	hepatic necrosis	J:57485
	increased circulating amylase level	J:57485
	increased circulating lipase level	J:57485
	increased susceptibility to induced morbidity/mortality	J:57485
	liver inflammation	J:57485
Pzp^tm1Vln/Pzp^tm1Vln involves: 129P2/OlaHsd * C57BL	abnormal bile color	J:28328
	decreased locomotor activity	J:28328
	decreased susceptibility to induced morbidity/mortality	J:28328
	decreased susceptibility to weight gain	J:28328
	disheveled coat	J:28328
	enlarged liver	J:28328
	gallstones	J:28328
	greasy coat	J:28328
	hepatic steatosis	J:28328
	normal homeostasis/metabolism phenotype	J:28328
	increased susceptibility to induced pancreatitis	J:28328
	normal liver/biliary system phenotype	J:28328
	normal neoplasm	J:28328
	pancreas inflammation	J:28328
	normal respiratory system phenotype	J:28328

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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