Abl1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
MGI:87859

78 phenotypes from 11 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abl1^m1/Abl1⁺ involves: 129S/SvEv	no abnormal phenotype detected	J:72519
Abl1^m1/Abl1^m1 B6.129-Abl1^m1	perinatal lethality, incomplete penetrance	J:156743
Abl1^m1/Abl1^m1 either: 129S/SvEv-Abl1^m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	abnormal B cell differentiation	J:14644
	abnormal immune system cell morphology	J:14644
	abnormal immune system organ morphology	J:14644
	abnormal spleen germinal center morphology	J:14644
	abnormal spleen morphology	J:14644
	abnormal spleen white pulp morphology	J:14644
	abnormal T cell number	J:14644
	abnormal thymus morphology	J:14644
	cataract	J:14644
	decreased body weight	J:14644
	decreased cranium height	J:14644
	decreased immature B cell number	J:14644
	decreased pre-B cell number	J:14644
	decreased pro-B cell number	J:14644
	decreased single-positive T cell number	J:14644
	decreased thymocyte number	J:14644
	eyelids open at birth	J:14644
	increased single-positive T cell number	J:14644
	increased susceptibility to infection	J:14644
	postnatal lethality, incomplete penetrance	J:14644
	premature death	J:14644
	spleen hypoplasia	J:14644
	thymus cortex hypoplasia	J:14644
	thymus hypoplasia	J:14644
Abl1^m1/Abl1^m1 involves: 129S/SvEv	abnormal B cell differentiation	J:28795
	abnormal bone marrow cell physiology	J:28795
	abnormal immune system cell morphology	J:34903
	abnormal splenocyte physiology	J:34903
	decreased mature B cell number	J:28795
	decreased pre-B cell number	J:28795
	decreased pro-B cell number	J:28795
Abl1^m1/Abl1^m1 involves: 129S/SvEv * C57BL/6	abnormal B cell calcium ion homeostasis	J:148105
	abnormal bone marrow cell physiology	J:148105
	abnormal lymphopoiesis	J:148105
	decreased pro-B cell number	J:148105
Abl1^tm1.1Gcos/Abl1⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal myogenesis	J:168843
Abl1^tm1.1Gcos/Abl1⁺ involves: 129S1/Sv * 129X1/SvJ	decreased physiological sensitivity to xenobiotic	J:168843
Abl1^tm1.1Gcos/Abl1^tm1.1Gcos involves: 129S1/Sv * 129X1/SvJ	abnormal myogenesis	J:168843
	decreased physiological sensitivity to xenobiotic	J:168843
Abl1^tm1.1Goff/Abl1^tm1.1Goff involves: C57BL/6	no abnormal phenotype detected	J:156743
Abl1^tm1Ajk/Abl1^tm1Ajk Tg(Nes-cre)1Kag/0 involves: 129S4/SvJae * C3H * C57BL/6	normal behavior/neurological phenotype	J:327648
	decreased susceptibility to injury	J:327648
	normal nervous system phenotype	J:327648
Abl1^tm1Goff/Abl1^tm1Goff involves: C57BL/6	abnormal heart ventricle morphology	J:156743
	enlarged heart	J:156743
	heart hyperplasia	J:156743
	perinatal lethality, incomplete penetrance	J:156743
	thick ventricular wall	J:156743
Abl1^tm1Goff/Abl1^tm1Goff Tg(Myh6-cre)2182Mds/0 involves: C57BL/6	normal cardiovascular system phenotype	J:156743
	neonatal lethality, complete penetrance	J:156743
	thick ventricular wall	J:156743
Abl1^tm1Mlg/Abl1^tm1Mlg 129S/SvEv-Abl1^tm1Mlg	postnatal lethality, incomplete penetrance	J:156743
Abl1^tm1Mlg/Abl1^tm1Mlg B6.129-Abl1^tm1Mlg	abnormal heart morphology	J:156743
	abnormal heart ventricle morphology	J:156743
	abnormal myocardial fiber morphology	J:156743
	abnormal myocardium compact layer morphology	J:156743
	abnormal trabecula carnea morphology	J:156743
	dilated heart atrium	J:156743
	enlarged heart	J:156743
	heart hyperplasia	J:156743
	increased fetal cardiomyocyte proliferation	J:156743
	increased heart ventricle size	J:156743
	increased heart weight	J:156743
	increased myocardial fiber number	J:156743
	myocardial fiber disarray	J:156743
	neonatal lethality, incomplete penetrance	J:156743
	postnatal lethality, incomplete penetrance	J:156743
	thick interventricular septum	J:156743
	thick ventricular wall	J:156743
Abl1^tm1Mlg/Abl1^tm1Mlg involves: 129S/SvEv * C57BL/6J	abnormal hepatocyte morphology	J:72875
	cachexia	J:72875
	normal cardiovascular system phenotype	J:156743
	decreased B cell number	J:72875
	decreased lymphocyte cell number	J:72875
	decreased survivor rate	J:72875
	decreased T cell number	J:72875
	decreased thymocyte number	J:72875
	enlarged esophagus	J:72875
	lung inflammation	J:72875
	perinatal lethality, incomplete penetrance	J:156743
	postnatal lethality, incomplete penetrance	J:72875, J:156743
	rectal prolapse	J:72875
	spleen atrophy	J:72875
	thymus atrophy	J:72875
Abl1^tm1Mlg/Abl1^tm1Mlg involves: 129S/SvEv * C57BL/6J * CBA	abnormal eye morphology	J:34643
	abnormal spleen morphology	J:34643
	decreased body size	J:34643
	decreased bone marrow cell number	J:34643
	decreased cranium height	J:34643
	decreased survivor rate	J:34643
	increased susceptibility to infection	J:34643
	postnatal lethality, incomplete penetrance	J:34643
	rectal prolapse	J:34643
Abl1^tm1Mlg/Abl1^tm1Mlg Tg(ACTB-Abl1I)1Spg/0 involves: 129S/SvEv C57BL/6J * CBA	decreased bone marrow cell number	J:34643
	normal mortality/aging	J:34643
Abl1^tm1Mlg/Abl1^tm1Mlg Tg(ACTB-Abl1IV)1Spg/0 involves: 129S/SvEv C57BL/6J * CBA	decreased bone marrow cell number	J:34643
	normal mortality/aging	J:34643
Abl1^tm1Mlg/Abl1^tm1Mlg Tg(ACTB-Abl1K290R)1Spg/0 involves: 129S/SvEv C57BL/6J * CBA	abnormal digestive system morphology	J:34643
	abnormal spleen morphology	J:34643
	decreased survivor rate	J:34643
	increased susceptibility to infection	J:34643
	postnatal lethality, incomplete penetrance	J:34643
Abl1^tm2.2Goff/Abl1^tm2.2Goff involves: 129P2/OlaHsd * C57BL/6J * FVB/N	abnormal cerebellar foliation	J:166211
	abnormal cerebellum development	J:166211
	decreased body size	J:166211
	ectopic cerebellar granule cells	J:166211
	neonatal lethality, incomplete penetrance	J:166211
	spleen atrophy	J:166211
	thymus atrophy	J:166211
Tg(Igh-Abl1)40Sco/0 involves: C57BL/6JWehi * SJL/JWehi	abnormal peripheral lymph node morphology	J:78204
	ascites	J:78204
	enlarged mesenteric lymph nodes	J:78204
	enlarged spleen	J:78204
	increased plasmacytoma incidence	J:78204

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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