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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Abl2
ABL proto-oncogene 2, non-receptor tyrosine kinase
MGI:87860
33 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Abl1tm1Ajk/Abl1tm1Ajk
Abl2tm1Ajk/Abl2tm1Ajk
Tg(Nes-cre)1Kag/?
involves: 129S4/SvJae 		abnormal cerebral cortex pyramidal cell morphology J:99296
normal mortality/aging J:99296
Abl1tm1Mlg/Abl1+
Abl2tm1Ajk/Abl2tm1Ajk
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J 		decreased body size J:51887
postnatal lethality, incomplete penetrance J:51887
Abl1tm1Mlg/Abl1tm1Mlg
Abl2tm1Ajk/Abl2+
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J 		abnormal peritoneum morphology J:51887
distended pericardium J:51887
edema J:51887
hemopericardium J:51887
hemoperitoneum J:51887
lethality throughout fetal growth and development, incomplete penetrance J:51887
pericardial edema J:51887
Abl1tm1Mlg/Abl1tm1Mlg
Abl2tm1Ajk/Abl2tm1Ajk
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J 		abnormal actin cytoskeleton morphology J:51887
abnormal embryonic neuroepithelium morphology J:51887
abnormal neuron differentiation J:51887
delayed neural tube closure J:51887
embryonic lethality during organogenesis, complete penetrance J:51887
hemopericardium J:51887
increased embryonic tissue cell apoptosis J:51887
Abl1tm2.1Goff/Abl1tm2.1Goff
Abl2tm1Ajk/Abl2tm1Ajk
Tg(Atoh1-cre)1Bfri/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA 		normal nervous system phenotype J:166211
Abl1tm2.1Goff/Abl1tm2.1Goff
Abl2tm1Ajk/Abl2tm1Ajk
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * C57BL/6J * SJL 		abnormal brain morphology J:166211
abnormal cerebellar layer morphology J:166211
abnormal cerebellar lobule formation J:166211
abnormal cerebellum fissure morphology J:166211
abnormal cerebellum morphology J:166211
abnormal cerebellum white matter morphology J:166211
absent cerebellar lobules J:166211
absent cerebellum fissure J:166211
decreased cerebellar granule cell precursor proliferation J:166211
ectopic Bergmann glia cells J:166211
ectopic cerebellar granule cells J:166211
ectopic Purkinje cell J:166211
impaired coordination J:166211
postnatal lethality, incomplete penetrance J:166211
reduced cerebellar foliation J:166211
small cerebellum J:166211
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory