Ace Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ace
angiotensin I converting enzyme
MGI:87874

78 phenotypes from 12 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ace^{tm1.1(KOMP)Vlcg}/Ace⁺ C57BL/6N-Ace^{tm1.1(KOMP)Vlcg}/MbpMmucd	abnormal embryo size	J:211773
	embryonic growth retardation	J:211773
	hyperactivity	J:211773
	increased basophil cell number	J:211773
Ace^{tm1.1(KOMP)Vlcg}/Ace^{tm1.1(KOMP)Vlcg} C57BL/6N-Ace^{tm1.1(KOMP)Vlcg}/MbpMmucd	abnormal embryo size	J:211773
	embryonic growth retardation	J:211773
	preweaning lethality, complete penetrance	J:211773
Ace^tm1Keb/Ace⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	normal cardiovascular system phenotype	J:33018
Ace^tm1Keb/Ace^tm1Keb involves: 129S1/Sv * 129X1/SvJ	abnormal response/metabolism to endogenous compounds	J:163902
	abnormal systemic arterial blood pressure	J:163902
	increased renin activity	J:163902
Ace^tm1Keb/Ace^tm1Keb involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal kidney arterial blood vessel morphology	J:33018
	abnormal kidney corticomedullary boundary morphology	J:33018
	abnormal kidney papilla morphology	J:33018
	abnormal renal artery morphology	J:33018
	abnormal urine homeostasis	J:33018
	decreased kidney weight	J:33018
	decreased litter size	J:33018
	decreased systemic arterial systolic blood pressure	J:33018
	decreased urine aldosterone level	J:33018
	decreased urine osmolality	J:33018
	dilated kidney calyx	J:33018
	hydronephrosis	J:33018
	increased circulating creatinine level	J:33018
	increased heart rate	J:33018
	increased urine potassium level	J:33018
	kidney inflammation	J:33018
	kidney medulla atrophy	J:33018
	kidney papillary atrophy	J:33018
	normal mortality/aging	J:33018
	polyuria	J:33018
	reduced male fertility	J:33018
Ace^tm1Mcf/Ace^tm1Mcf Not Specified	abnormal kidney medulla morphology	J:32114
	abnormal kidney medullary ray morphology	J:32114
	abnormal kidney pelvis morphology	J:32114
	abnormal kidney vasculature morphology	J:32114
	decreased urine osmolality	J:32114
	dilated renal glomerular capsule	J:32114
	increased blood urea nitrogen level	J:32114
	kidney cortex atrophy	J:32114
	kidney inflammation	J:32114
	kidney medulla cyst	J:32114
	postnatal lethality, incomplete penetrance	J:32114
	normal reproductive system phenotype	J:32114
	tubulointerstitial nephritis	J:32114
Ace^tm1Unc/Ace⁺ B6.129P2-Ace^tm1Unc	normal homeostasis/metabolism phenotype	J:72577
Ace^tm1Unc/Ace⁺ involves: 129P2/OlaHsd	increased heart rate	J:42519
Ace^tm1Unc/Ace⁺ involves: 129P2/OlaHsd	increased heart weight	J:42519
Ace^tm1Unc/Ace⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal epididymal fat pad morphology	J:128859
	hypotension	J:25284
	increased body weight	J:128859
	increased insulin secretion	J:128859
	postnatal lethality, incomplete penetrance	J:25284
	normal reproductive system phenotype	J:46177
Ace^tm1Unc/Ace^tm1Unc involves: 129P2/OlaHsd	decreased angiotensin II level	J:100334
	decreased circulating angiotensin II level	J:100334
	decreased susceptibility to injury	J:100334
Ace^tm1Unc/Ace^tm1Unc involves: 129P2/OlaHsd * C57BL/6J	abnormal kidney vasculature morphology	J:25284
	abnormal renal glomerulus morphology	J:25284
	decreased fertilization frequency	J:46177
	decreased litter size	J:25284
	hypotension	J:25284
	impaired binding of sperm to zona pellucida	J:46177
	impaired fertilization	J:46177
	impaired sperm migration in female genital tract	J:46177
	kidney cortex atrophy	J:25284
	kidney inflammation	J:25284
	preweaning lethality, incomplete penetrance	J:25284
	reduced male fertility	J:25284
	renal tubule atrophy	J:25284
	normal reproductive system phenotype	J:25284, J:46177
Ace^tm2Keb/Ace⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased systemic arterial systolic blood pressure	J:40475
Ace^tm2Keb/Ace^tm2Keb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal kidney arterial blood vessel morphology	J:40475
	decreased litter size	J:40475
	decreased systemic arterial systolic blood pressure	J:40475
	decreased urine osmolality	J:40475
	dilated kidney calyx	J:40475
	increased glomerular capsule space	J:40475
	polyuria	J:40475
	reduced male fertility	J:40475
Ace^tm2Unc/Ace^tm2Unc involves: 129P2/OlaHsd * C57BL/6J	abnormal kidney vasculature morphology	J:46177
	kidney atrophy	J:46177
	postnatal lethality, incomplete penetrance	J:46177
	normal reproductive system phenotype	J:46177
Ace^tm3Keb/Ace^tm3Keb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal cardiovascular system phenotype	J:83178
	normal liver/biliary system phenotype	J:83178
	normal renal/urinary system phenotype	J:83178
Ace^tm4Keb/Ace^tm4Keb involves: 129S1/Sv * 129X1/SvJ	abnormal kidney morphology	J:83894
	abnormal kidney pelvis morphology	J:83894
	abnormal kidney vasculature morphology	J:83894
	decreased hematocrit	J:83894
	decreased kidney weight	J:83894
	decreased systemic arterial systolic blood pressure	J:83894
	decreased urine osmolality	J:83894
	kidney medulla hypoplasia	J:83894
Ace^tm7Keb/Ace^tm7Keb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	atrial fibrillation	J:92397
	decreased survivor rate	J:92397
	decreased systemic arterial systolic blood pressure	J:92397
	dilated heart	J:92397
	increased heart atrium size	J:92397
	premature death	J:92397
Ace^tm8.1Keb/Ace^tm8.1Keb involves: 129 * C57BL/6	decreased angiotensin I-converting enzyme activity	J:163454
Ace^tm8.1Keb/Ace^tm8.1Keb involves: 129 * C57BL/6	normal homeostasis/metabolism phenotype	J:163454
Ace^tm8.1Keb/Ace^tm8.1Keb involves: 129 * C57BL/6 * FVB/N	abnormal angiotensin I-converting enzyme activity	J:163902
	abnormal circulating protein level	J:163902
	abnormal response/metabolism to endogenous compounds	J:163902
	abnormal systemic arterial blood pressure	J:163902
	normal cardiovascular system phenotype	J:163902
	decreased angiotensin I-converting enzyme activity	J:163902
	decreased circulating angiotensin II level	J:163902
	decreased urine osmolality	J:163902
	increased renin activity	J:163902
	normal renal/urinary system phenotype	J:163902
Ace^tm8Keb/Ace^tm8Keb involves: 129	abnormal cardiovascular system physiology	J:163902
	abnormal homeostasis	J:163902
	abnormal kidney morphology	J:163902
Ace^tm9Keb/Ace^tm9Keb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal circulating angiotensinogen level	J:185888
	abnormal kidney medulla morphology	J:185888
	abnormal kidney pelvis morphology	J:185888
	abnormal renal artery morphology	J:185888
	abnormal systemic arterial blood pressure	J:185888
	abnormal urine osmolality	J:185888
	decreased angiotensin I-converting enzyme activity	J:185888
	decreased circulating angiotensinogen level	J:185888
	decreased systemic arterial systolic blood pressure	J:185888
	decreased urine osmolality	J:185888
	normal homeostasis/metabolism phenotype	J:185888
	increased fluid intake	J:185888
	increased renin activity	J:185888
	kidney inflammation	J:185888
	polyuria	J:185888

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