Ace Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ace
angiotensin I converting enzyme
MGI:87874

34 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ace^tm1Keb/Ace^tm5Keb involves: 129S1/Sv * 129X1/SvJ	decreased angiotensin I-converting enzyme activity	J:89512
Ace^tm1Keb/Ace^tm5Keb involves: 129S1/Sv * 129X1/SvJ	increased circulating renin level	J:89512
Ace^tm1Unc/Ace^tm1Unc Ace2^tm1Pngr/Y involves: 129P2/OlaHsd	abnormal kidney morphology	J:77232
	decreased angiotensin II level	J:100334
	decreased circulating angiotensin II level	J:100334
	decreased susceptibility to injury	J:100334
	hypotension	J:77232
Ace^tm1Unc/Ace^tm1Unc Ace2^tm1Pngr/Ace2^tm1Pngr involves: 129P2/OlaHsd	abnormal kidney morphology	J:77232
	decreased angiotensin II level	J:100334
	decreased circulating angiotensin II level	J:100334
	decreased susceptibility to injury	J:100334
	hypotension	J:77232
Ace^tm3Unc/Ace⁺ B6.129P2-Ace^tm3Unc	albuminuria	J:72577
Ace^tm3Unc/Ace⁺ B6.129P2-Ace^tm3Unc	increased systemic arterial blood pressure	J:72577
Ace^tm3Unc/Ace⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal epididymal fat pad morphology	J:128859
	abnormal kidney cortex morphology	J:42519
	abnormal renal glomerulus morphology	J:42519
	decreased body weight	J:128859
	decreased heart rate	J:42519
	decreased heart weight	J:42519
	decreased insulin secretion	J:128859
	increased food intake	J:128859
Ace^tm3Unc/Ace^tm3Unc involves: 129P2/OlaHsd * C57BL/6J	abnormal kidney cortex morphology	J:42519
	abnormal renal glomerulus morphology	J:42519
	decreased heart rate	J:42519
	decreased heart weight	J:42519
Ace^tm4Keb/Ace^tm4Keb Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	abnormal kidney vasculature morphology	J:83894
	abnormal response/metabolism to endogenous compounds	J:83894
	decreased hematocrit	J:83894
	decreased kidney weight	J:83894
	decreased systemic arterial systolic blood pressure	J:83894
	decreased urine osmolality	J:83894
	kidney cyst	J:83894
	vascular inflammation	J:83894
Ace^tm5Keb/Ace^tm5Keb involves: 129S1/Sv * 129X1/SvJ	normal cardiovascular system phenotype	J:89512
	decreased angiotensin I-converting enzyme activity	J:89512
	normal homeostasis/metabolism phenotype	J:163902
	normal renal/urinary system phenotype	J:89512
Ace^tm5Keb/Ace^tm5Keb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased susceptibility to injury	J:163454
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:163454
	increased angiotensin I-converting enzyme activity	J:163454
Ace^tm6Keb/Ace⁺ involves: 129 * C57BL/6	decreased tumor growth/size	J:122178
Ace^tm6Keb/Ace^tm6Keb involves: 129 * C57BL/6	abnormal interleukin level	J:122178
	abnormal tumor morphology	J:122178
	decreased tumor growth/size	J:122178
	increased T cell number	J:122178
Ace^tm6Keb/Ace^tm6Keb involves: 129 * C57BL/6 * CD-1	decreased tumor growth/size	J:122178

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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