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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
MGI:87888
35 phenotypes from 10 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chrna4tm1.1Stit/Chrna4tm1.1Stit
B6.129X1-Chrna4tm1.1Stit 		abnormal behavioral response to addictive substance J:180872
normal behavior/neurological phenotype J:180872
decreased body temperature J:180872
impaired conditioned place preference behavior J:180872
Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S/SvEv * 129S1/Sv * C57BL/6 		abnormal synaptic dopamine release J:174505
enhanced behavioral response to nicotine J:174505
impaired behavioral response to nicotine J:174505
impaired conditioned place preference behavior J:174505
Chrna4tm1.2Tmcg/Chrna4tm1.2Tmcg
involves: 129S/SvEv * 129S1/Sv * C57BL/6 		abnormal synaptic dopamine release J:174505
decreased neurotransmitter release J:174505
impaired behavioral response to nicotine J:174505
impaired conditioned place preference behavior J:174505
Chrna4tm1Dra/Chrna4tm1Dra
involves: 129S4/SvJae * C57BL/6 		abnormal behavioral response to addictive substance J:64208
abnormal brain wave pattern J:97020
abnormal emotion/affect behavior J:97020
abnormal locomotor activation J:64208
abnormal response to new environment J:64208
normal behavior/neurological phenotype J:125305
decreased grooming behavior J:64208
increased anxiety-related response J:64208
increased susceptibility to pharmacologically induced seizures J:97020
increased vertical activity J:64208
Chrna4tm1Jbou/Chrna4+
either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J) 		abnormal brain wave pattern J:118273
abnormal inhibitory postsynaptic currents J:118273
abnormal nervous system physiology J:118273
behavioral arrest J:118273
clonic seizures J:118273
seizures J:118273
Chrna4tm1Jbou/Chrna4tm1Jbou
either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J) 		abnormal brain wave pattern J:118273
abnormal nervous system physiology J:118273
behavioral arrest J:118273
clonic seizures J:118273
seizures J:118273
Chrna4tm1Jpc/Chrna4tm1Jpc
B6.Cg-Chrna4tm1Jpc 		normal nervous system phenotype J:77377
Chrna4tm1Jpc/Chrna4tm1Jpc
involves: C57BL/6 		abnormal brain morphology J:54505
abnormal nicotine-mediated receptor currents J:54505
decreased chemically-elicited antinociception J:54505
decreased IgG level J:103908
decreased immunoglobulin level J:103908
normal immune system phenotype J:103908
increased IgG level J:103908
Chrna4tm1Lst/Chrna4+
involves: C57BL/6 		abnormal motor learning J:67863
normal behavior/neurological phenotype J:67863
enhanced behavioral response to nicotine J:67863
impaired behavioral response to addictive substance J:67863
increased anxiety-related response J:67863
increased exploration in new environment J:67863
Chrna4tm1Lst/Chrna4tm1Lst
involves: C57BL/6 		decreased dopaminergic neuron number J:67863
neonatal lethality, complete penetrance J:67863
Chrna4tm2.1Dra/Chrna4+
B6.129S1-Chrna4tm2.1Dra 		abnormal behavioral response to addictive substance J:125305
normal behavior/neurological phenotype J:125305
impaired behavioral response to nicotine J:125305
Chrna4tm2.1Dra/Chrna4+
involves: 129S1/Sv * C57BL/6 * CD-1 		abnormal behavioral response to addictive substance J:125305
normal behavior/neurological phenotype J:125305
impaired behavioral response to nicotine J:125305
Chrna4tm2.1Dra/Chrna4+
involves: 129S1/Sv * CD-1 		abnormal behavioral response to addictive substance J:125305
normal behavior/neurological phenotype J:125305
impaired behavioral response to nicotine J:125305
Chrna4tm2Jbou/Chrna4+
either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J) 		abnormal brain wave pattern J:118273
abnormal nervous system physiology J:118273
behavioral arrest J:118273
clonic seizures J:118273
seizures J:118273
Chrna4tm2Jbou/Chrna4tm2Jbou
either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J) 		abnormal brain wave pattern J:118273
abnormal nervous system physiology J:118273
behavioral arrest J:118273
clonic seizures J:118273
seizures J:118273
Chrna4tm2Lst/Chrna4tm2Lst
involves: 129S1/Sv * C57BL/6 		enhanced behavioral response to nicotine J:93873
enhanced conditioned place preference behavior J:93873
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory