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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chrne
cholinergic receptor, nicotinic, epsilon polypeptide
MGI:87894
21 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chrnem1Btlr/Chrnem1Btlr
C57BL/6J-Chrnem1Btlr 		decreased body weight J:216046
premature death J:216046
Chrnetm1Jrs/Chrnetm1Jrs
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal motor nerve collateral sprouting J:74958
abnormal neuromuscular synapse morphology J:74958
decreased locomotor activity J:74958
premature death J:74958
skeletal muscle atrophy J:74958
slow postnatal weight gain J:74958
weakness J:74958
Chrnetm1Vwi/Chrnetm1Vwi
involves: 129P2/OlaHsd * C57BL/6 		abnormal miniature endplate potential J:36557
abnormal neuromuscular synapse morphology J:36557
abnormal PNS synaptic transmission J:36557
abnormal skeletal muscle morphology J:36557
decreased body weight J:36557
decreased grip strength J:36557
decreased muscle weight J:36557
impaired skeletal muscle contractility J:36557
premature death J:36557
skeletal muscle atrophy J:36557
weakness J:36557
Tg(Ckm-Chrne*L269F)5Cgz/?
involves: FVB/NJ 		abnormal action potential J:193524
abnormal endplate potential J:193524
abnormal miniature endplate potential J:193524
abnormal neuromuscular synapse morphology J:193524
abnormal PNS synaptic transmission J:193524
abnormal skeletal muscle fiber morphology J:193524
decreased locomotor activity J:193524
increased physiological sensitivity to xenobiotic J:193524
increased pulmonary respiratory rate J:193524
muscle weakness J:193524
skeletal muscle fiber degeneration J:193524
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory