Actb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Actb
actin, beta
MGI:87904

18 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Actb^em1Erv/Actb^em1Erv involves: C57BL/6	abnormal outer hair cell stereociliary bundle morphology	J:265862
	decreased outer hair cell stereocilia number	J:265862
	impaired hearing	J:265862
	increased susceptibility to age-related hearing loss	J:265862
	normal muscle phenotype	J:265862
	short outer hair cell stereocilia	J:265862
Actb^tm1.1Erv/Actb^tm1.1Erv Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N	normal hearing/vestibular/ear phenotype	J:167543
	postnatal lethality, incomplete penetrance	J:167543
Actb^tm1.1Erv/Actb^tm1.1Erv Tg(Atoh1-cre)1Bfri/? involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N	abnormal cochlear hair cell stereociliary bundle morphology	J:167543
	normal hearing/vestibular/ear phenotype	J:167543
	increased or absent threshold for auditory brainstem response	J:167543
	increased susceptibility to age-related hearing loss	J:167543
	short cochlear hair cell stereocilia	J:167543
Actb^tm1Alj/Actb^tm1Alj involves: 129S1/Sv * 129X1/SvJ * CD-1	prenatal lethality, complete penetrance	J:67904
Actb^tm1Bhr/Actb^tm1Bhr involves: 129S7/SvEvBrd * C57BL/6	embryonic growth retardation	J:46634
Actb^tm1Bhr/Actb^tm1Bhr involves: 129S7/SvEvBrd * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:46634
Actb^tm1Dost/Actb^tm1Dost involves: 129P2/OlaHsd * C57BL/6	embryonic lethality at implantation, complete penetrance	J:136574
Actb^tm1Itl/Actb^tm1Itl involves: 129S/SvEv	no abnormal phenotype detected	J:187804
Actb^tm1Npa/Actb⁺ involves: BALB/cJ	decreased body weight	J:129639
Actb^tm1Npa/Actb^tm1Npa involves: BALB/cJ	embryonic lethality during organogenesis, complete penetrance	J:129639
Actb^tm2Npa/Actb⁺ involves: BALB/c	decreased body size	J:129105
Tg(KRT14-EGFP/Actb)50Efu/0 Not Specified	no abnormal phenotype detected	J:156846

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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