Actb Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Actb
actin, beta
MGI:87904

51 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	increased circulating ketone body level	J:91350
	postnatal lethality, complete penetrance	J:91350
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Camk2a-cre)#Szi/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Hsp70-1-cre)6Arge/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Nes-cre)1Kln/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Syn1-cre)671Jxm/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actb^{tm1(PyVT)Arge}/Actb⁺ involves: 129S1/Sv	increased hemangioma incidence	J:87544
	increased mammary adenocarcinoma incidence	J:87544
	premature death	J:87544
Actb^{tm1(PyVT)Arge}/Actb⁺ Wap^tm1(cre)Arge/Wap⁺ involves: 129S1/Sv	decreased cardiac muscle contractility	J:87544
	increased mammary adenocarcinoma incidence	J:87544
	premature death	J:87544
Actb^{tm1(PyVT)Arge}/Actb⁺ Tg(Hsp70-1-cre)1Arge/0 involves: 129S1/Sv * C57BL/6J * CBA	embryonic lethality between implantation and somite formation, complete penetrance	J:87544
Actb^{tm1.1(tetO-COP4/EYFP)Kftnk}/Actb⁺ Tg(Mlc1-tTA)2Rhn/0 involves: 129 129S4/SvJaeSor * C57BL/6 * CBA	abnormal astrocyte physiology	J:193127
	abnormal neuron physiology	J:193127
Actb^tm1.1Erv/Actb^tm1.1Erv Actg1^tm1.2Erv/Actg1^tm1.2Erv Tg(Atoh1-cre)1Bfri/? involves: 129/Sv * C57BL/6 * CBA * FVB/N	abnormal cochlear hair cell stereociliary bundle morphology	J:167543
Actb^tm2(Tag)Arge/Actb⁺ involves: 129S1/Sv	increased sarcoma incidence	J:87544
Actb^tm2(Tag)Arge/Actb⁺ Tg(Hsp70-1-cre)1Arge/0 involves: 129S1/Sv * C57BL/6J * CBA	abnormal smooth muscle morphology	J:87544
	abnormal uterus morphology	J:87544
	enlarged gallbladder	J:87544
	enlarged seminal vesicle	J:87544
	increased leiomyosarcoma incidence	J:87544
Actb^{tm3.1(Sirt1)Npa}/Actb⁺ involves: 129/Sv * C57BL/6 * C57BL/6J	abnormal motor coordination/balance	J:160212
	normal behavior/neurological phenotype	J:160212
	decreased body weight	J:160212
	decreased circulating adiponectin level	J:160212
	decreased circulating cholesterol level	J:160212
	decreased circulating free fatty acids level	J:160212
	decreased circulating HDL cholesterol level	J:160212
	decreased circulating insulin level	J:160212
	decreased circulating LDL cholesterol level	J:160212
	decreased circulating leptin level	J:160212
	decreased epididymal fat pad weight	J:160212
	decreased fasting circulating glucose level	J:160212
	delayed fertility	J:160212
	normal homeostasis/metabolism phenotype	J:160212
	improved glucose tolerance	J:160212
	increased food intake	J:160212
	increased oxygen consumption	J:160212
	preweaning lethality, incomplete penetrance	J:160212
Actb^{tm3.1(Sirt1)Npa}/Actb⁺ Sirt1^tm1Mcby/Sirt1^tm1Mcby involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	normal growth/size/body region phenotype	J:160212
	normal reproductive system phenotype	J:160212
	normal vision/eye phenotype	J:160212
Actb^{tm3.1(Sirt1)Npa}/Actb^{tm3.1(Sirt1)Npa} involves: 129/Sv * C57BL/6 * C57BL/6J	preweaning lethality, complete penetrance	J:160212
Actb^{tm4(cre/ERT2)Npa}/Actb⁺ Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa involves: BALB/cJ * C57BL/6	abnormal lipid homeostasis	J:199525
	abnormal lymph node morphology	J:199525
	abnormal regulatory T cell number	J:199525
	abnormal type IV hypersensitivity reaction	J:199525
	decreased follicular B cell number	J:199525
	decreased marginal zone B cell number	J:199525
	decreased single-positive T cell number	J:199525
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:199525
	normal growth/size/body region phenotype	J:199525
	increased thymocyte number	J:199525
	normal mortality/aging	J:199525
	spleen hypoplasia	J:199525

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