Actc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Actc1
actin, alpha, cardiac muscle 1
MGI:87905

24 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Actc1^em1(IMPC)Mbp/Actc1^em1(IMPC)Mbp C57BL/6N-Actc1^em1(IMPC)Mbp/MbpMmucd	preweaning lethality, complete penetrance	J:211773
Actc1^tm1.1Buck/Actc1⁺ involves: 129P2/OlaHsd	no abnormal phenotype detected	J:84604
Actc1^tm1Jll/Actc1^tm1Jll involves: 129P2/OlaHsd * Black Swiss	abnormal myocardial fiber morphology	J:102007
	abnormal sarcomere morphology	J:40165
	decreased body size	J:40165
	delayed heart development	J:102007
	disorganized myocardium	J:102007
	enlarged heart	J:102007
	increased cardiomyocyte apoptosis	J:102007
	lethality throughout fetal growth and development, incomplete penetrance	J:40165
	muscle degeneration	J:102007
	myocardial fiber degeneration	J:102007
	myocardial fiber disarray	J:40165
	postnatal lethality, complete penetrance	J:40165
Tg(Myh6-Actc1*R312H)307Iko/? involves: C57BL/6	abnormal cardiovascular system physiology	J:178587
	abnormal myocardial fiber physiology	J:178587
	cardiac fibrosis	J:178587
	decreased cardiac muscle contractility	J:178587
	decreased QRS amplitude	J:178587
	dilated cardiomyopathy	J:178587
	dilated heart left ventricle	J:178587
	enlarged heart	J:178587
	increased cardiomyocyte apoptosis	J:178587
	increased heart rate	J:178587
	increased heart weight	J:178587
	myocardial fiber degeneration	J:178587
	premature death	J:178587

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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