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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Acvr1
activin A receptor, type 1
MGI:87911
111 phenotypes from 10 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Acvr1tm1.1(KOMP)Vlcg/Acvr1+
C57BL/6N-Acvr1tm1.1(KOMP)Vlcg/MbpMmucd 		increased circulating total protein level J:211773
Acvr1tm1.1(KOMP)Vlcg/Acvr1tm1.1(KOMP)Vlcg
C57BL/6N-Acvr1tm1.1(KOMP)Vlcg/MbpMmucd 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Acvr1tm1.1Mak/Acvr1tm1.1Mak
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal embryo development J:285841
prenatal lethality, complete penetrance J:285841
Acvr1tm1.1Vk/Acvr1tm1.1Vk
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal embryonic epiblast morphology J:117234
abnormal gastrulation J:117234
abnormal mesoderm development J:117234
abnormal primitive streak morphology J:117234
decreased embryo size J:117234
embryonic growth arrest J:117234
Acvr1tm1Bhr/Acvr1tm1Bhr
involves: 129S7/SvEvBrd * C57BL/6 		abnormal embryonic epiblast morphology J:57670
abnormal mesoderm development J:57670
abnormal primitive streak formation J:57670
absent allantois J:57670
decreased embryo size J:57670
disorganized embryonic tissue J:57670
embryonic growth arrest J:57670
embryonic lethality between implantation and somite formation, complete penetrance J:57670
Acvr1tm1Bhr/Acvr1tm1Bhr
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal embryonic epiblast morphology J:117234
abnormal gastrulation J:117234
abnormal mesoderm development J:117234
abnormal primitive streak morphology J:117234
decreased embryo size J:117234
embryonic growth arrest J:117234
Acvr1tm1Emsh/Acvr1+
C57BL/6-Acvr1tm1Emsh 		neonatal lethality, complete penetrance J:194134
Acvr1tm1Emsh/Acvr1+
chimera involves: BALB/c * C57BL/6 * CD-1 		abnormal cervical vertebrae morphology J:194134
abnormal costovertebral joint morphology J:194134
abnormal joint mobility J:194134
abnormal joint morphology J:194134
abnormal motor capabilities/coordination/movement J:194134
abnormal phalanx morphology J:194134
broad femur neck J:194134
ectopic bone J:194134
edema J:194134
increased apoptosis J:194134
increased inflammatory response J:194134
increased osteochondroma incidence J:194134
short femur neck J:194134
short metatarsal bones J:194134
skeletal muscle degeneration J:194134
vertebral fusion J:194134
Acvr1tm1Enl/Acvr1tm1Enl
involves: 129S4/SvJae * BALB/c 		abnormal ectoderm development J:54394
abnormal embryo development J:54394
abnormal gastrulation J:54394
abnormal primitive streak formation J:54394
abnormal visceral endoderm morphology J:54394
absent allantois J:54394
absent amnion J:54394
absent amniotic folds J:54394
absent chorion J:54394
absent mesoderm J:54394
decreased embryo size J:54394
embryonic lethality during organogenesis, complete penetrance J:54394
thick embryonic epiblast J:54394
Acvr1tm1Glh/Acvr1+
Tg(Cdh5-cre)7Mlia/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		normal skeleton phenotype J:257905
Acvr1tm1Glh/Acvr1+
Myod1tm2.1(icre)Glh/Myod1+
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		normal skeleton phenotype J:257905
Acvr1tm1Mak/Acvr1+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal brain development J:285841
abnormal brainstem morphology J:285841
abnormal glial cell physiology J:285841
ataxia J:285841
muscle spasm J:285841
normal neoplasm J:285841
preweaning lethality, incomplete penetrance J:285841
Acvr1tm1Vk/Acvr1tm1.1Vk
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal aortic arch and aortic arch branch attachment J:90988
abnormal aortic arch morphology J:90988
abnormal brachiocephalic trunk morphology J:90988
abnormal cardiac neural crest cell migration J:90988
abnormal cardiac outflow tract development J:90988
abnormal cartilage morphology J:90453
abnormal frontal bone squamous part morphology J:90453
abnormal malleus morphology J:90453
abnormal mandible morphology J:90453
abnormal mandibular fossa morphology J:90453
abnormal Meckel's cartilage morphology J:90453
abnormal palatal shelf elevation J:90453
abnormal pharyngeal arch artery morphology J:90988
abnormal sixth pharyngeal arch artery morphology J:90988
abnormal suckling behavior J:90453
abnormal third pharyngeal arch artery morphology J:90988
abnormal zygomatic arch morphology J:90453
absent cardiac neural crest cells J:90988
absent mandibular symphysis J:90453
absent retrotympanic process J:90453
absent temporal bone zygomatic process J:90453
absent temporomandibular joint J:90453
absent zygomatic bone J:90453
cleft secondary palate J:90453
conotruncal ridge hypoplasia J:90988
decreased cardiac neural crest cell number J:90988
delayed palatal shelf elevation J:90453
enlarged heart J:90988
impaired cardiac neural crest cell differentiation J:90988
increased heart right ventricle size J:90988
large anterior fontanelle J:90453
lethality throughout fetal growth and development, incomplete penetrance J:90453, J:90988
mandible hypoplasia J:90453
neonatal lethality, complete penetrance J:90988
persistent truncus arteriosus J:90988
retroesophageal right subclavian artery J:90988
short malleus manubrium J:90453
short mandible J:90453
shortened head J:90453
small mandibular coronoid process J:90453
small temporal bone squamous part J:90453
ventricular septal defect J:90988
Acvr1tm1Vk/Acvr1tm1.1Vk
Tg(Myh6-cre)2182Mds/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		normal cardiovascular system phenotype J:103532
Acvr1tm1Vk/Acvr1tm1.1Vk
Tg(Tek-cre)12Flv/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 		abnormal atrioventricular cushion morphology J:103532
abnormal atrioventricular septum morphology J:103532
abnormal atrioventricular valve development J:103532
abnormal cardiac epithelial to mesenchymal transition J:103532
abnormal heart morphology J:103532
abnormal vascular endothelial cell differentiation J:103532
atrial septal defect J:103532
cardiovascular shunt J:103532
decreased atrioventricular cushion size J:103532
lethality throughout fetal growth and development, incomplete penetrance J:103532
ventricular septal defect J:103532
Acvr1tm2.1Vlcg/Acvr1+
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6J * C57BL/6NTac * SJL/J 		abnormal digit morphology J:239136
abnormal long bone epiphyseal plate morphology J:239136
abnormal motor capabilities/coordination/movement J:239136
abnormal skeleton development J:239136
decreased length of long bones J:239136
decreased width of hypertrophic chondrocyte zone J:239136
increased bone ossification J:239136
increased chondrocyte proliferation J:239136
short femur J:239136
short humerus J:239136
short radius J:239136
short tibia J:239136
Acvr1tm2.1Vlcg/Acvr1+
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac 		increased bone ossification J:234069
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory