Acvr2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Acvr2b
activin receptor IIB
MGI:87912

35 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Acvr2b^{tm1.1(KOMP)Vlcg}/Acvr2b⁺ C57BL/6N-Acvr2b^{tm1.1(KOMP)Vlcg}/Ucd	abnormal kidney morphology	J:211773
	enlarged kidney	J:211773
	polycystic kidney	J:211773
Acvr2b^{tm1.1(KOMP)Vlcg}/Acvr2b^{tm1.1(KOMP)Vlcg} C57BL/6N-Acvr2b^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, complete penetrance	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo involves: 129S4/SvJae * FVB/N	vertebral transformation	J:114533
Acvr2b^tm1.1Zuk/Acvr2b^tm1.1Zuk Tg(Myl1-cre)1Sjl/0 involves: 129P2/OlaHsd * C57BL/6 * SJL/J	increased skeletal muscle weight	J:188599
Acvr2b^tm1Enl/Acvr2b^tm1Enl either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6J)	abnormal bronchus morphology	J:42018
	abnormal cardiac outflow tract development	J:42018
	abnormal direction of heart looping	J:42018
	abnormal heart development	J:42018
	abnormal heart position or orientation	J:42018
	abnormal liver morphology	J:42018
	abnormal rib morphology	J:42018
	abnormal spleen morphology	J:42018
	absent kidney	J:42018
	atrial septal defect	J:42018
	cyanosis	J:42018
	dextrocardia	J:42018
	increased thoracic vertebrae number	J:42018
	mesocardia	J:42018
	postnatal lethality, complete penetrance	J:42018
	postnatal lethality, incomplete penetrance	J:42018
	renal hypoplasia	J:42018
	rib fusion	J:42018
	right atrial isomerism	J:42018
	right pulmonary isomerism	J:42018
	single kidney	J:42018
	small spleen	J:42018
	thoracic vertebral transformation	J:42018
	transposition of great arteries	J:42018
	ventricular septal defect	J:42018
Acvr2b^tm1Enl/Acvr2b^tm1Enl involves: 129S4/SvJae	abnormal left-right axis patterning	J:114533
	lumbar vertebral transformation	J:95124
	right pulmonary isomerism	J:114533
	sacral vertebral transformation	J:95124
	transposition of great arteries	J:114533
	vertebral transformation	J:114533
Acvr2b^tm1Spo/Acvr2b^tm1Spo involves: 129S4/SvJae	abnormal left-right axis patterning	J:114533
	lumbar vertebral transformation	J:114533
	right pulmonary isomerism	J:114533
	transposition of great arteries	J:114533
	vertebral transformation	J:114533
Acvr2b^tm1Spo/Acvr2b^tm1Spo involves: 129S4/SvJae * C57BL/6J	abnormal left-right axis patterning	J:114533
	lumbar vertebral transformation	J:114533
	vertebral transformation	J:114533

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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