Add2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Add2
adducin 2
MGI:87919

32 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Add2^tm1Feb/Add2^tm1Feb B6.129-Add2^tm1Feb	anemia	J:63047
	decreased hematocrit	J:63047
	decreased hemoglobin content	J:63047
	decreased mean corpuscular hemoglobin	J:63047
	hypertension	J:71038
	increased circulating bilirubin level	J:63047
	increased erythrocyte osmotic fragility	J:63047
	increased mean corpuscular hemoglobin concentration	J:63047
	increased pulse pressure	J:71038
	increased spleen weight	J:63047
	increased systemic arterial diastolic blood pressure	J:71038
	increased systemic arterial systolic blood pressure	J:71038
	microcytosis	J:63047
	poikilocytosis	J:63047
	reticulocytosis	J:63047
Add2^tm1Llp/Add2^tm1Llp B6.129S4-Add2^tm1Llp/LlpJ	abnormal CNS synaptic transmission	J:98208
	abnormal contextual conditioning behavior	J:98208
	abnormal cued conditioning behavior	J:98208
	abnormal spatial learning	J:98208
	enhanced paired-pulse facilitation	J:98208
	impaired synaptic plasticity	J:98208
	increased post-tetanic potentiation	J:98208
	reduced long-term potentiation	J:98208
Add2^tm1Llp/Add2^tm1Llp involves: 129S4/SvJae * C57BL/6J	abnormal erythrocyte morphology	J:161920
	abnormal erythrocyte physiology	J:71029
	anemia	J:71029, J:161920
	anisopoikilocytosis	J:71029, J:161920
	decreased hematocrit	J:71029, J:161920
	decreased mean corpuscular volume	J:71029
	enlarged spleen	J:71029
	increased erythrocyte osmotic fragility	J:161920
	increased kidney iron level	J:71029
	increased liver iron level	J:71029
	increased mean corpuscular hemoglobin concentration	J:71029
	increased spleen iron level	J:71029
	microcytosis	J:71029
	reticulocytosis	J:71029, J:161920
	spherocytosis	J:71029, J:161920

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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