Adk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adk
adenosine kinase
MGI:87930

39 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adk^{em1(IMPC)Ccpcz}/Adk⁺ C57BL/6N-Adk^{em1(IMPC)Ccpcz}/Ccpcz	abnormal lung morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spine curvature	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	decreased exploration in new environment	J:211773
	decreased locomotor activity	J:211773
	enlarged lung	J:211773
	enlarged thymus	J:211773
	increased anxiety-related response	J:211773
	increased lung tissue damping	J:211773
Adk^{em1(IMPC)Ccpcz}/Adk^{em1(IMPC)Ccpcz} C57BL/6N-Adk^{em1(IMPC)Ccpcz}/Ccpcz	preweaning lethality, complete penetrance	J:211773
Adk^tm1Bois/Adk^tm1Bois involves: 129P3/JEmsJ * C57BL/6	abnormal body temperature homeostasis	J:81518
	abnormal homeostasis	J:81518
	abnormal nucleotide metabolism	J:81518
	apnea	J:81518
	decreased body size	J:81518
	decreased body weight	J:81518
	delayed eyelid opening	J:81518
	hepatic steatosis	J:81518
	macrovesicular hepatic steatosis	J:81518
	microvesicular hepatic steatosis	J:81518
	pale liver	J:81518
	postnatal growth retardation	J:81518
	postnatal lethality, complete penetrance	J:81518
Adk^tm2Bois/Adk^tm2Bois Tg(Nes-cre)1Kln/0 involves: C57BL/6 * SJL	abnormal associative learning	J:237189
	abnormal CNS synaptic transmission	J:237189
	abnormal excitatory postsynaptic potential	J:237189
	abnormal synaptic plasticity	J:237189
	convulsive seizures	J:237189
	enhanced long-term potentiation	J:237189
	environmentally induced seizures	J:237189
	impaired contextual conditioning behavior	J:237189
	increased susceptibility to pharmacologically induced seizures	J:237189
Tg(UBC-Adk)1Bois/0 B6;129P3-Adk^tm1Bois Tg(UBC-Adk)1Bois	abnormal brain wave pattern	J:105483
	abnormal seizure response to pharmacological agent	J:105483
	gliosis	J:105483
	hyperactivity	J:105483
	nonconvulsive seizures	J:105483

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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