Adra2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adra2b
adrenergic receptor, alpha 2b
MGI:87935

21 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adra2b^tm1Gsb/Adra2b⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	normal cardiovascular system phenotype	J:89315
	normal renal/urinary system phenotype	J:89315
Adra2b^tm1Gsb/Adra2b^tm1Gsb B6.129-Adra2b^tm1Gsb	abnormal lung development	J:166788
	abnormal pulmonary alveolus morphology	J:166788
	atelectasis	J:166788
	cyanosis	J:166788
	decreased birth weight	J:166788
	decreased lung weight	J:166788
	dilated heart right ventricle	J:166788
	normal hematopoietic system phenotype	J:166788
	increased mesenchymal cell proliferation involved in lung development	J:166788
	neonatal lethality, incomplete penetrance	J:166788
	respiratory failure	J:166788
	slow postnatal weight gain	J:166788
	thick pulmonary interalveolar septum	J:166788
Adra2b^tm1Gsb/Adra2b^tm1Gsb involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal fertility/fecundity	J:34819, J:58591
	abnormal vasoconstriction	J:34819
	normal behavior/neurological phenotype	J:89316
	normal cardiovascular system phenotype	J:34819, J:89317
	normal homeostasis/metabolism phenotype	J:89316
	postnatal lethality	J:34819
Tg(PDGFB-Adra2b)13Hag/0 involves: FVB	increased systemic arterial systolic blood pressure	J:158792

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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